Validation of the Fatty Liver Index for identifying non-alcoholic fatty liver disease in a Kenyan population
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Validation of the Fatty Liver Index for identifying non-alcoholic fatty liver disease in a Kenyan population. / Lajeunesse-Trempe, Fannie; Boit, Michael K.; Kaduka, Lydia U.; De Lucia-Rolfe, Emanuella; Baass, Alexis; Paquette, Martine; Piché, Marie Eve; Tchernof, André; Christensen, Dirk L.
I: Tropical Medicine and International Health, Bind 28, Nr. 10, 2023, s. 830-838.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Validation of the Fatty Liver Index for identifying non-alcoholic fatty liver disease in a Kenyan population
AU - Lajeunesse-Trempe, Fannie
AU - Boit, Michael K.
AU - Kaduka, Lydia U.
AU - De Lucia-Rolfe, Emanuella
AU - Baass, Alexis
AU - Paquette, Martine
AU - Piché, Marie Eve
AU - Tchernof, André
AU - Christensen, Dirk L.
N1 - Publisher Copyright: © 2023 The Authors Tropical Medicine & International Health Published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Background and Aim: Fatty Liver Index (FLI) is a simple clinical scoring system estimating non-alcoholic fatty liver disease (NAFLD). It is validated in European-descent and Asian populations, but not in sub-Saharan Africans. The aim of this study is to evaluate the validity of the FLI for predicting NAFLD in a population from Kenya. Methods: Participants were recruited from a community-based study conducted in Kenya. NAFLD was diagnosed using hepatic ultrasonography. Clinical, anthropometrical, biochemical and lifestyle data were obtained. The accuracy and cut-off point of the FLI to detect NAFLD were evaluated by area under the receiver operator characteristic curve and the maximum Youden index analysis. Results: A total of 640 participants (94 with NAFLD) were included. Mean age was 37.4 ± 0.4 years and 58.7% were women. Mean body mass index (BMI) was 22.3 ± 0.2 kg/m2 and waist circumference (WC) 79.1 ± 0.4 cm. A total of 15 (2.3%) participants were diagnosed with type 2 diabetes and 65 (10.2%) with obesity (BMI ≥ 30 kg/m2). AUROC of FLI for predicting NAFLD was 0.80 (95% CI 0.74–0.85), which was significantly higher compared to individual components gamma-glutamyl transferase and triglycerides (p < 0.05), but not compared to anthropometric parameters BMI (AUROC of 0.83, 95% CI 0.79–0.88) and WC (AUROC of 0.81, 95% CI 0.76–0.87). Conclusions: FLI is a simple valid scoring system to use in rural and urban Kenyan adults. However, this index might not be superior to BMI or WC to predict NAFLD, and those measurements might therefore be more appropriate in limited settings.
AB - Background and Aim: Fatty Liver Index (FLI) is a simple clinical scoring system estimating non-alcoholic fatty liver disease (NAFLD). It is validated in European-descent and Asian populations, but not in sub-Saharan Africans. The aim of this study is to evaluate the validity of the FLI for predicting NAFLD in a population from Kenya. Methods: Participants were recruited from a community-based study conducted in Kenya. NAFLD was diagnosed using hepatic ultrasonography. Clinical, anthropometrical, biochemical and lifestyle data were obtained. The accuracy and cut-off point of the FLI to detect NAFLD were evaluated by area under the receiver operator characteristic curve and the maximum Youden index analysis. Results: A total of 640 participants (94 with NAFLD) were included. Mean age was 37.4 ± 0.4 years and 58.7% were women. Mean body mass index (BMI) was 22.3 ± 0.2 kg/m2 and waist circumference (WC) 79.1 ± 0.4 cm. A total of 15 (2.3%) participants were diagnosed with type 2 diabetes and 65 (10.2%) with obesity (BMI ≥ 30 kg/m2). AUROC of FLI for predicting NAFLD was 0.80 (95% CI 0.74–0.85), which was significantly higher compared to individual components gamma-glutamyl transferase and triglycerides (p < 0.05), but not compared to anthropometric parameters BMI (AUROC of 0.83, 95% CI 0.79–0.88) and WC (AUROC of 0.81, 95% CI 0.76–0.87). Conclusions: FLI is a simple valid scoring system to use in rural and urban Kenyan adults. However, this index might not be superior to BMI or WC to predict NAFLD, and those measurements might therefore be more appropriate in limited settings.
KW - African populations
KW - ethnicity
KW - Fatty Liver Index
KW - hepatic steatosis
KW - non-alcoholic fatty liver disease
U2 - 10.1111/tmi.13927
DO - 10.1111/tmi.13927
M3 - Journal article
C2 - 37650501
AN - SCOPUS:85169168442
VL - 28
SP - 830
EP - 838
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
SN - 1360-2276
IS - 10
ER -
ID: 365703978