This study aims to analyze the quality of life, challenges, threats and health of
migrants/refugees living in Portugal during the COVID-19 pandemic in 2020/2021. This is a descriptive, cross-sectional study. 330 migrants/refugees that live in Portugal participated in this study, with an average age of 35.25±11.21 years, of which 62% (n=183) are female. 42.2% (n=98) have Portuguese nationality and 38.8% (n=90) have temporary documents. Regarding COVID-19, 7% (n=15) tested positive and 16.1% (n=34) reported that someone close to them tested/is positive. A higher quality of life is related to greater adherence to measures to prevent COVID-19 transmission, less need to search in various sources for information on COVID-19 prevention, less physical and psychological symptoms and more coping strategies. The migrant/refugee population generally lives in more precarious situations compared to the local population. To this fact is added the current public
health crisis, material and social deprivation (which they already faced before the pandemic) and health problems. This study results reveal the importance of universal interventions that promote the integration of the migrant and refugee population in Portugal. These interventions should include logistical, social and health support and promote the development of personal and socio-emotional skills in order to increase well-being and social cohesion. It is intended to sensitize policy makers to the importance of psychosocial interventions with the migrant/refugee population.