Low to moderate average alcohol consumption and binge drinking in early pregnancy: Effects on choice reaction time and information processing time in five-year-old children

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Dokumenter

  • Tina R. Kilburn
  • Hanne Lise Falgreen Eriksen
  • Mette Underbjerg
  • Poul Thorsen
  • Mortensen, Erik Lykke
  • Nils Inge Landrø
  • Leiv S. Bakketeig
  • Jakob Grove
  • Claus Sværke
  • Ulrik Schiøler Kesmodel

Background Deficits in information processing may be a core deficit after fetal alcohol exposure. This study was designed to investigate the possible effects of weekly low to moderate maternal alcohol consumption and binge drinking episodes in early pregnancy on choice reaction time (CRT) and information processing time (IPT) in young children. Method Participants were sampled based on maternal alcohol consumption during pregnancy. At the age of 60-64 months, 1,333 children were administered a modified version of the Sternberg paradigm to assess CRT and IPT. In addition, a test of general intelligence (WPPSI-R) was administered. Results Adjusted for a wide range of potential confounders, this study showed no significant effects of average weekly maternal alcohol consumption during pregnancy on CRT or IPT. There was, however, an indication of slower CRT associated with binge drinking episodes in gestational weeks 1-4. Conclusion This study observed no significant effects of average weekly maternal alcohol consumption during pregnancy on CRT or IPT as assessed by the Sternberg paradigm. However, there were some indications of CRT being associated with binge drinking during very early pregnancy. Further large-scale studies are needed to investigate effects of different patterns of maternal alcohol consumption on basic cognitive processes in offspring.

OriginalsprogEngelsk
Artikelnummere0138611
TidsskriftPLoS ONE
Vol/bind10
Udgave nummer9
ISSN1932-6203
DOI
StatusUdgivet - 18 sep. 2015

Bibliografisk note

Publisher Copyright:
© 2015 Kilburn et al.

ID: 275899649