TY - JOUR

T1 - Intergenerational transmission of tobacco smoking

T2 - The role of the child's behavioral difficulties. Data from the Danish National Birth cohort (DNBC)

AU - Fekom, Mathilde

AU - Nguyen, Tri-Long

AU - Lepeule, Johanna

AU - Nakamura, Aurélie

AU - Keyes, Katherine

AU - Martins, Silvia

AU - Strandberg-Larsen, Katrine

AU - Melchior, Maria

N1 - Copyright © 2023 Elsevier B.V. All rights reserved.

PY - 2024

Y1 - 2024

N2 - AIMS: This study explores the role of offspring behavioral difficulties in the intergeneration transmission of tobacco smoking.METHODS: This longitudinal cohort study is based on children born in Denmark in 1996-2003 participating in the Danish National Birth Cohort (DNBC), followed-up until 18years of age. We included mother-child pairs with complete data regarding the exposure (4 trajectories of maternal daily smoking quantity during pregnancy: low, intermediate/stable, intermediate/decreasing and high), outcome (offspring daily smoking status at 18 years) and mediator (offspring symptoms of hyperactivity-inattention at 11 years), that is 24,588 mother-child pairs.RESULTS: In our study population, during pregnancy respectively 86.2%, 6.80%, 4.08% and 2.97% mothers belonged to the low, intermediate/stable, intermediate/decreasing and high smoking trajectory groups. After controlling for covariates using propensity scores, the direct effect of maternal smoking in pregnancy on offspring smoking in adolescence was statistically significant, especially when the mother belonged to the intermediate/stable smoking trajectory group (ORIPW = 2.09, 95% CI: 1.70 - 2.61) or to the high smoking trajectory group (ORIPW = 2.08, 95% CI: 1.52 - 3.11) compared to the low smoking trajectory group. None of the indirect effects of maternal smoking in pregnancy were statistically significant, and neither were the proportions mediated.CONCLUSION: Maternal pregnancy smoking seems to have an influence on offspring smoking in early adulthood, which does not appear to be mediated by offspring behavioral difficulties. Women should be strongly encouraged to quit smoking in pregnancy to reduce both short and long-term health risks among their offspring.

AB - AIMS: This study explores the role of offspring behavioral difficulties in the intergeneration transmission of tobacco smoking.METHODS: This longitudinal cohort study is based on children born in Denmark in 1996-2003 participating in the Danish National Birth Cohort (DNBC), followed-up until 18years of age. We included mother-child pairs with complete data regarding the exposure (4 trajectories of maternal daily smoking quantity during pregnancy: low, intermediate/stable, intermediate/decreasing and high), outcome (offspring daily smoking status at 18 years) and mediator (offspring symptoms of hyperactivity-inattention at 11 years), that is 24,588 mother-child pairs.RESULTS: In our study population, during pregnancy respectively 86.2%, 6.80%, 4.08% and 2.97% mothers belonged to the low, intermediate/stable, intermediate/decreasing and high smoking trajectory groups. After controlling for covariates using propensity scores, the direct effect of maternal smoking in pregnancy on offspring smoking in adolescence was statistically significant, especially when the mother belonged to the intermediate/stable smoking trajectory group (ORIPW = 2.09, 95% CI: 1.70 - 2.61) or to the high smoking trajectory group (ORIPW = 2.08, 95% CI: 1.52 - 3.11) compared to the low smoking trajectory group. None of the indirect effects of maternal smoking in pregnancy were statistically significant, and neither were the proportions mediated.CONCLUSION: Maternal pregnancy smoking seems to have an influence on offspring smoking in early adulthood, which does not appear to be mediated by offspring behavioral difficulties. Women should be strongly encouraged to quit smoking in pregnancy to reduce both short and long-term health risks among their offspring.

KW - Pregnancy

KW - Adolescent

KW - Humans

KW - Female

KW - Adult

KW - Longitudinal Studies

KW - Birth Cohort

KW - Prenatal Exposure Delayed Effects/epidemiology

KW - Tobacco Smoking

KW - Mothers

KW - Denmark/epidemiology

U2 - 10.1016/j.drugalcdep.2023.111056

DO - 10.1016/j.drugalcdep.2023.111056

M3 - Journal article

C2 - 38128363

VL - 255

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

M1 - 111056

ER -