Instrumental variable estimation of the causal hazard ratio

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Cox's proportional hazards model is one of the most popular statistical models to evaluate associations of exposure with a censored failure time outcome. When confounding factors are not fully observed, the exposure hazard ratio estimated using a Cox model is subject to unmeasured confounding bias. To address this, we propose a novel approach for the identification and estimation of the causal hazard ratio in the presence of unmeasured confounding factors. Our approach is based on a binary instrumental variable, and an additional no-interaction assumption in a first stage regression of the treatment on the IV and unmeasured confounders. We propose, to the best of our knowledge, the first consistent estimator of the (population) causal hazard ratio within an instrumental variable framework. A version of our estimator admits a closed-form representation. We derive the asymptotic distribution of our estimator, and provide a consistent estimator for its asymptotic variance. Our approach is illustrated via simulation studies and a data application. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftBiometrics
Vol/bind79
Udgave nummer2
Sider (fra-til) 539-550
Antal sider12
ISSN0006-341X
DOI
StatusUdgivet - 2023

Bibliografisk note

This article is protected by copyright. All rights reserved.

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