Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort

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Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort. / Deen, Laura; Clark, Alice; Hougaard, Karin Sørig; Petersen, Kajsa Ugelvig; Frederiksen, Marie; Wise, Lauren A.; Wesselink, Amelia K.; Meyer, Harald William; Bonde, Jens Peter; Tøttenborg, Sandra Søgaard.

I: Environmental Research, Bind 237, 117000, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Deen, L, Clark, A, Hougaard, KS, Petersen, KU, Frederiksen, M, Wise, LA, Wesselink, AK, Meyer, HW, Bonde, JP & Tøttenborg, SS 2023, 'Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort', Environmental Research, bind 237, 117000. https://doi.org/10.1016/j.envres.2023.117000

APA

Deen, L., Clark, A., Hougaard, K. S., Petersen, K. U., Frederiksen, M., Wise, L. A., Wesselink, A. K., Meyer, H. W., Bonde, J. P., & Tøttenborg, S. S. (2023). Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort. Environmental Research, 237, [117000]. https://doi.org/10.1016/j.envres.2023.117000

Vancouver

Deen L, Clark A, Hougaard KS, Petersen KU, Frederiksen M, Wise LA o.a. Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort. Environmental Research. 2023;237. 117000. https://doi.org/10.1016/j.envres.2023.117000

Author

Deen, Laura ; Clark, Alice ; Hougaard, Karin Sørig ; Petersen, Kajsa Ugelvig ; Frederiksen, Marie ; Wise, Lauren A. ; Wesselink, Amelia K. ; Meyer, Harald William ; Bonde, Jens Peter ; Tøttenborg, Sandra Søgaard. / Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort. I: Environmental Research. 2023 ; Bind 237.

Bibtex

@article{8b4081111e2243dcb24d67dfdfeb668a,

title = "Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort",

abstract = "Background: Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. Methods: The register-based {\textquoteleft}Health Effects of PCBs in Indoor Air{\textquoteright} (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. Results: We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCByear) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCByear, the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). Discussion: We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.",

keywords = "Environmental pollutants, Lower-chlorinated PCBs, PCBs, Volatile PCBs",

author = "Laura Deen and Alice Clark and Hougaard, {Karin S{\o}rig} and Petersen, {Kajsa Ugelvig} and Marie Frederiksen and Wise, {Lauren A.} and Wesselink, {Amelia K.} and Meyer, {Harald William} and Bonde, {Jens Peter} and T{\o}ttenborg, {Sandra S{\o}gaard}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

doi = "10.1016/j.envres.2023.117000",

language = "English",

volume = "237",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort

AU - Deen, Laura

AU - Clark, Alice

AU - Hougaard, Karin Sørig

AU - Petersen, Kajsa Ugelvig

AU - Frederiksen, Marie

AU - Wise, Lauren A.

AU - Wesselink, Amelia K.

AU - Meyer, Harald William

AU - Bonde, Jens Peter

AU - Tøttenborg, Sandra Søgaard

PY - 2023

Y1 - 2023

N2 - Background: Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. Methods: The register-based ‘Health Effects of PCBs in Indoor Air’ (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. Results: We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCByear) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCByear, the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). Discussion: We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.

AB - Background: Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. Methods: The register-based ‘Health Effects of PCBs in Indoor Air’ (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. Results: We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCByear) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCByear, the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). Discussion: We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.

KW - Environmental pollutants

KW - Lower-chlorinated PCBs

KW - PCBs

KW - Volatile PCBs

U2 - 10.1016/j.envres.2023.117000

DO - 10.1016/j.envres.2023.117000

M3 - Journal article

C2 - 37634693

AN - SCOPUS:85171427837

VL - 237

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

M1 - 117000

ER -

ID: 369567148