All-cause mortality among Danish nursing home residents before and during the COVID-19 pandemic: a nationwide cohort study
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All-cause mortality among Danish nursing home residents before and during the COVID-19 pandemic : a nationwide cohort study. / Andersen, Mikkel Porsborg; Mills, Elisabeth Helen Anna; Meddis, Alessandra; Sørensen, Kathrine Kold; Butt, Jawad Haider; Køber, Lars; Poulsen, Henrik Enghusen; Phelps, Matthew; Gislason, Gunnar; Christensen, Helle Collatz; Schou, Morten; Fosbøl, Emil L.; Gerds, Thomas Alexander; Kragholm, Kristian; Torp-Pedersen, Christian.
I: European Journal of Epidemiology, Bind 38, 2023, s. 523–531.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - All-cause mortality among Danish nursing home residents before and during the COVID-19 pandemic
T2 - a nationwide cohort study
AU - Andersen, Mikkel Porsborg
AU - Mills, Elisabeth Helen Anna
AU - Meddis, Alessandra
AU - Sørensen, Kathrine Kold
AU - Butt, Jawad Haider
AU - Køber, Lars
AU - Poulsen, Henrik Enghusen
AU - Phelps, Matthew
AU - Gislason, Gunnar
AU - Christensen, Helle Collatz
AU - Schou, Morten
AU - Fosbøl, Emil L.
AU - Gerds, Thomas Alexander
AU - Kragholm, Kristian
AU - Torp-Pedersen, Christian
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - A substantial part of mortality during the COVID-19-pandemic occurred among nursing home residents which caused alarm in many countries. We investigate nursing home mortality in relation to the expected mortality prior to the pandemic. This nationwide register-based study included all 135,501 Danish nursing home residents between 2015 until October 6, 2021. All-cause mortality rates were calculated using a standardization method on sex and age distribution of 2020. Survival probability and lifetime lost for 180 days was calculated using Kaplan Meier estimates. Of 3,587 COVID-19 related deaths, 1137 (32%) occurred among nursing home residents. The yearly all-cause mortality rates per 100,000 person-years in 2015, 2016, and 2017 were 35,301 (95% CI: 34,671–35,943), 34,801 (95% CI: 34,180–35,432), and 35,708 (95% CI: 35,085–36,343), respectively. Slightly elevated mortality rates per 100,000 person-years were seen in 2018, 2019, 2020, and 2021 of 38,268 (95% CI: 37,620–38,929), 36,956 (95% CI: 36,323–37,600), 37,475 (95% CI: 36,838–38,122), and 38,536 (95% CI: 37,798–39,287), respectively. For SARS-CoV-2-infected nursing home residents, lifetime lost difference was 42 days (95% CI: 38–46) in 2020 versus non-infected in 2018. Among vaccinated in 2021, lifetime lost difference was 25 days (95% CI: 18–32) for SARS-CoV-2-infected versus non-infected. Even though a high proportion of COVID-19 fatalities took place in nursing homes and SARS-CoV-2-infection increased the risk of individual death, the annual mortality was only slightly elevated. For future epidemics or pandemics reporting numbers of fatal cases in relation to expected mortality is critical.
AB - A substantial part of mortality during the COVID-19-pandemic occurred among nursing home residents which caused alarm in many countries. We investigate nursing home mortality in relation to the expected mortality prior to the pandemic. This nationwide register-based study included all 135,501 Danish nursing home residents between 2015 until October 6, 2021. All-cause mortality rates were calculated using a standardization method on sex and age distribution of 2020. Survival probability and lifetime lost for 180 days was calculated using Kaplan Meier estimates. Of 3,587 COVID-19 related deaths, 1137 (32%) occurred among nursing home residents. The yearly all-cause mortality rates per 100,000 person-years in 2015, 2016, and 2017 were 35,301 (95% CI: 34,671–35,943), 34,801 (95% CI: 34,180–35,432), and 35,708 (95% CI: 35,085–36,343), respectively. Slightly elevated mortality rates per 100,000 person-years were seen in 2018, 2019, 2020, and 2021 of 38,268 (95% CI: 37,620–38,929), 36,956 (95% CI: 36,323–37,600), 37,475 (95% CI: 36,838–38,122), and 38,536 (95% CI: 37,798–39,287), respectively. For SARS-CoV-2-infected nursing home residents, lifetime lost difference was 42 days (95% CI: 38–46) in 2020 versus non-infected in 2018. Among vaccinated in 2021, lifetime lost difference was 25 days (95% CI: 18–32) for SARS-CoV-2-infected versus non-infected. Even though a high proportion of COVID-19 fatalities took place in nursing homes and SARS-CoV-2-infection increased the risk of individual death, the annual mortality was only slightly elevated. For future epidemics or pandemics reporting numbers of fatal cases in relation to expected mortality is critical.
KW - All-cause mortality
KW - Care home facilities
KW - COVID-19
KW - Nursing home residents
KW - SARS-CoV-2
U2 - 10.1007/s10654-023-00994-6
DO - 10.1007/s10654-023-00994-6
M3 - Journal article
C2 - 37012504
AN - SCOPUS:85151436617
VL - 38
SP - 523
EP - 531
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
SN - 0393-2990
ER -
ID: 345061932