Reproductive hormones, bone mineral content, body composition, and testosterone therapy in boys and adolescents with Klinefelter syndrome
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Reproductive hormones, bone mineral content, body composition, and testosterone therapy in boys and adolescents with Klinefelter syndrome. / Krabbe, Hans Valdemar López; Petersen, Jørgen Holm; Asserhøj, Louise Laub; Johannsen, Trine Holm; Christiansen, Peter; Jensen, Rikke Beck; Cleemann, Line Hartvig; Hagen, Casper P.; Priskorn, Lærke; Jørgensen, Niels; Main, Katharina M.; Juul, Anders; Aksglaede, Lise.
I: Endocrine Connections, Bind 12, Nr. 7, e230031, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Reproductive hormones, bone mineral content, body composition, and testosterone therapy in boys and adolescents with Klinefelter syndrome
AU - Krabbe, Hans Valdemar López
AU - Petersen, Jørgen Holm
AU - Asserhøj, Louise Laub
AU - Johannsen, Trine Holm
AU - Christiansen, Peter
AU - Jensen, Rikke Beck
AU - Cleemann, Line Hartvig
AU - Hagen, Casper P.
AU - Priskorn, Lærke
AU - Jørgensen, Niels
AU - Main, Katharina M.
AU - Juul, Anders
AU - Aksglaede, Lise
N1 - Publisher Copyright: © 2023 the author(s) Published by Bioscientifica Ltd.
PY - 2023
Y1 - 2023
N2 - Adult patients with Klinefelter syndrome (KS) are characterized by a highly variable phenotype, including tall stature, obesity, and hypergonadotropic hypogonadism, as well as an increased risk of developing insulin resistance, metabolic syndrome, and osteoporosis. Most adults need testosterone replacement therapy (TRT), whereas the use of TRT during puberty has been debated. In this retrospective, observational study, reproductive hormones and whole-body dual-energy x-ray absorptiometry-derived body composition and bone mineral content were standardized to age-related standard deviation scores in 62 patients with KS aged 5.9–20.6 years. Serum concentrations of total testosterone and inhibin B were low, whereas luteinizing hormone and follicle-stimulating hormone were high in patients before TRT. Despite normal body mass index, body fat percentage and the ratio between android fat percentage and gynoid fat percentage were significantly higher in the entire group irrespective of treatment status. In patients evaluated before and during TRT, a tendency toward a more beneficial body composition with a significant reduction in the ratio between android fat percentage and gynoid fat percentage during TRT was found. Bone mineral content (BMC) did not differ from the reference, but BMC corrected for bone area was significantly lower when compared to the reference. This study confirms that patients with KS have an unfavorable body composition and an impaired bone mineral status already during childhood and adolescence. Systematic studies are needed to evaluate whether TRT during puberty will improve these parameters.
AB - Adult patients with Klinefelter syndrome (KS) are characterized by a highly variable phenotype, including tall stature, obesity, and hypergonadotropic hypogonadism, as well as an increased risk of developing insulin resistance, metabolic syndrome, and osteoporosis. Most adults need testosterone replacement therapy (TRT), whereas the use of TRT during puberty has been debated. In this retrospective, observational study, reproductive hormones and whole-body dual-energy x-ray absorptiometry-derived body composition and bone mineral content were standardized to age-related standard deviation scores in 62 patients with KS aged 5.9–20.6 years. Serum concentrations of total testosterone and inhibin B were low, whereas luteinizing hormone and follicle-stimulating hormone were high in patients before TRT. Despite normal body mass index, body fat percentage and the ratio between android fat percentage and gynoid fat percentage were significantly higher in the entire group irrespective of treatment status. In patients evaluated before and during TRT, a tendency toward a more beneficial body composition with a significant reduction in the ratio between android fat percentage and gynoid fat percentage during TRT was found. Bone mineral content (BMC) did not differ from the reference, but BMC corrected for bone area was significantly lower when compared to the reference. This study confirms that patients with KS have an unfavorable body composition and an impaired bone mineral status already during childhood and adolescence. Systematic studies are needed to evaluate whether TRT during puberty will improve these parameters.
KW - body composition
KW - bone mineral content
KW - Klinefelter syndrome
KW - truncal obesity
U2 - 10.1530/EC-23-0031
DO - 10.1530/EC-23-0031
M3 - Journal article
C2 - 37010084
AN - SCOPUS:85162766824
VL - 12
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 7
M1 - e230031
ER -
ID: 362680799