TY - JOUR

T1 - Parental cardiovascular disease and cardiovascular disease risk factors in the offspring

T2 - The Diet, Cancer and Health cohorts

AU - Petersen, Kristina E

AU - Rosthøj, Susanne

AU - Halkjær, Jytte

AU - Loft, Steffen

AU - Tjønneland, Anne

AU - Olsen, Anja

N1 - Copyright © 2023 Elsevier B.V. All rights reserved.

PY - 2024

Y1 - 2024

N2 - BACKGROUND AND AIMS: Cardiovascular disease (CVD) aggregates in families and offspring with parental CVD may have adverse risk factor levels long time before the potential onset of CVD. We compared risk factor levels in offspring of parents with atherosclerotic CVD (ASCVD) and parents with no ASCVD at different parental ages at onset.METHODS: The study included 5751 participants (median age: 50 years) of the Diet, Cancer and Health - Next Generations study. Measurements included blood pressure, body composition and lipid fractions. Information on parental ASCVD and age at disease onset was obtained through register linkage. Parental ASCVD was defined as myocardial infarction, ischemic stroke or peripheral artery disease occurring <70 years, prematurely (mothers: <65 years fathers: <55 years), divided into age categories or using a broader classification of CVD. Linear regression models using Generalized Estimating Equations were used for analysis. Analyses were adjusted for age, sex, education, smoking, alcohol intake, physical activity and some additionally for BMI.RESULTS: Offspring with parental ASCVD had a higher blood pressure, waist circumference, BMI, visceral adipose tissue, percentage of body fat and non-HDL cholesterol levels, but not other lipid levels, compared to offspring with no parental ASCVD (all p < 0.01). Overall, the same patterns were observed for parental ASCVD occurring prematurely and using a broader CVD classification.CONCLUSIONS: Offspring with parental ASCVD had a higher blood pressure, higher body composition measures and higher non-HDL cholesterol levels compared to offspring with no parental ASCVD. Findings were overall consistent across different classifications of parental ASCVD.

AB - BACKGROUND AND AIMS: Cardiovascular disease (CVD) aggregates in families and offspring with parental CVD may have adverse risk factor levels long time before the potential onset of CVD. We compared risk factor levels in offspring of parents with atherosclerotic CVD (ASCVD) and parents with no ASCVD at different parental ages at onset.METHODS: The study included 5751 participants (median age: 50 years) of the Diet, Cancer and Health - Next Generations study. Measurements included blood pressure, body composition and lipid fractions. Information on parental ASCVD and age at disease onset was obtained through register linkage. Parental ASCVD was defined as myocardial infarction, ischemic stroke or peripheral artery disease occurring <70 years, prematurely (mothers: <65 years fathers: <55 years), divided into age categories or using a broader classification of CVD. Linear regression models using Generalized Estimating Equations were used for analysis. Analyses were adjusted for age, sex, education, smoking, alcohol intake, physical activity and some additionally for BMI.RESULTS: Offspring with parental ASCVD had a higher blood pressure, waist circumference, BMI, visceral adipose tissue, percentage of body fat and non-HDL cholesterol levels, but not other lipid levels, compared to offspring with no parental ASCVD (all p < 0.01). Overall, the same patterns were observed for parental ASCVD occurring prematurely and using a broader CVD classification.CONCLUSIONS: Offspring with parental ASCVD had a higher blood pressure, higher body composition measures and higher non-HDL cholesterol levels compared to offspring with no parental ASCVD. Findings were overall consistent across different classifications of parental ASCVD.

KW - Female

KW - Humans

KW - Middle Aged

KW - Cardiovascular Diseases/diagnosis

KW - Risk Factors

KW - Parents

KW - Hypertension/complications

KW - Diet/adverse effects

KW - Cholesterol

KW - Neoplasms/epidemiology

U2 - 10.1016/j.atherosclerosis.2023.117406

DO - 10.1016/j.atherosclerosis.2023.117406

M3 - Journal article

C2 - 38141480

VL - 388

JO - Journal of atherosclerosis research

JF - Journal of atherosclerosis research

SN - 1567-5688

M1 - 117406

ER -