TY - JOUR

T1 - New Onset Diabetes Mellitus after Kidney Transplantation in Denmark

AU - Hornum, Mette

AU - Jørgensen, Kaj Anker

AU - Hansen, Jesper Melchior

AU - Nielsen, FT

AU - Christensen, KB

AU - Mathiesen, ER

AU - Feldt-Rasmussen, B

PY - 2010/4

Y1 - 2010/4

N2 - Background and objectives: This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in aprospective study of 97 nondiabetic uremic patients.Design, setting, participants, & measurements: Included were 57 kidney recipients (Tx group, age 39 13 years) and 40uremic patients remaining on the waiting list for kidney transplantation (uremic controls, age 47 11 years). All wereexamined at baseline before possible transplantation and after 12 months. The prevalence of diabetes, prediabetes, insulinsensitivity index (ISI), and insulin secretion index (Isecr) were estimated using an oral glucose tolerance test with measurementsof plasma glucose and plasma insulin.Results: One year after transplantation NODM was present in 14% (8 of 57) compared with 5% (2 of 40) in the uremic controlgroup (P 0.01). ISI in the Tx group deteriorated from 6.8 3.9 before transplantation to 4.9 2.8 at 12 months aftertransplantation (P 0.005), and a slight increase in Isecr from 37 19 to 46 22 (P 0.02) was seen. No significant changesoccurred in the uremic controls (ISI was 7.9 5 and 8.5 5, and Isecr was 31 17 and 28 15). Using multivariate ordinallogistic regression, pre-Tx ISI and age predicted NODM (odds ratios: 0.82, P 0.01 and 1.06, P 0.02, respectively).Conclusions: One year after kidney transplantation, NODM was present in 14% of patients. This was mainly caused by anincrease in insulin resistance and was observed despite improvement in insulin secretion.

AB - Background and objectives: This study aimed to investigate the development of new-onset diabetes mellitus (NODM) in aprospective study of 97 nondiabetic uremic patients.Design, setting, participants, & measurements: Included were 57 kidney recipients (Tx group, age 39 13 years) and 40uremic patients remaining on the waiting list for kidney transplantation (uremic controls, age 47 11 years). All wereexamined at baseline before possible transplantation and after 12 months. The prevalence of diabetes, prediabetes, insulinsensitivity index (ISI), and insulin secretion index (Isecr) were estimated using an oral glucose tolerance test with measurementsof plasma glucose and plasma insulin.Results: One year after transplantation NODM was present in 14% (8 of 57) compared with 5% (2 of 40) in the uremic controlgroup (P 0.01). ISI in the Tx group deteriorated from 6.8 3.9 before transplantation to 4.9 2.8 at 12 months aftertransplantation (P 0.005), and a slight increase in Isecr from 37 19 to 46 22 (P 0.02) was seen. No significant changesoccurred in the uremic controls (ISI was 7.9 5 and 8.5 5, and Isecr was 31 17 and 28 15). Using multivariate ordinallogistic regression, pre-Tx ISI and age predicted NODM (odds ratios: 0.82, P 0.01 and 1.06, P 0.02, respectively).Conclusions: One year after kidney transplantation, NODM was present in 14% of patients. This was mainly caused by anincrease in insulin resistance and was observed despite improvement in insulin secretion.

U2 - 10.2215/CJN.05360709

DO - 10.2215/CJN.05360709

M3 - Journal article

C2 - 20167685

VL - 5

SP - 709

EP - 716

JO - Clinical Journal of American Society of Nephrology.

JF - Clinical Journal of American Society of Nephrology.

SN - 1555-9041

IS - 4

ER -