Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project

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Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort : The ELAPSE project. / Nagel, Gabriele; Chen, Jie; Jaensch, Andrea; Skodda, Lea; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Katsouyanni, Klea; Ketzel, Matthias; Leander, Karin; Magnusson, Patrik K.E.; Pershagen, Göran; Rizzuto, Debora; Samoli, Evangelia; Severi, Gianluca; Stafoggia, Massimo; Tjønneland, Anne; Vermeulen, Roel C.H.; Wolf, Kathrin; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole; Weinmayr, Gudrun.

I: International Journal of Cancer, Bind 154, Nr. 11, 2024, s. 1900-1910.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nagel, G, Chen, J, Jaensch, A, Skodda, L, Rodopoulou, S, Strak, M, de Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, B, Hvidtfeldt, UA, Katsouyanni, K, Ketzel, M, Leander, K, Magnusson, PKE, Pershagen, G, Rizzuto, D, Samoli, E, Severi, G, Stafoggia, M, Tjønneland, A, Vermeulen, RCH, Wolf, K, Zitt, E, Brunekreef, B, Hoek, G, Raaschou-Nielsen, O & Weinmayr, G 2024, 'Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project', International Journal of Cancer, bind 154, nr. 11, s. 1900-1910. https://doi.org/10.1002/ijc.34864

APA

Nagel, G., Chen, J., Jaensch, A., Skodda, L., Rodopoulou, S., Strak, M., de Hoogh, K., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B., Hvidtfeldt, U. A., Katsouyanni, K., Ketzel, M., Leander, K., ... Weinmayr, G. (2024). Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project. International Journal of Cancer, 154(11), 1900-1910. https://doi.org/10.1002/ijc.34864

Vancouver

Nagel G, Chen J, Jaensch A, Skodda L, Rodopoulou S, Strak M o.a. Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project. International Journal of Cancer. 2024;154(11):1900-1910. https://doi.org/10.1002/ijc.34864

Author

Nagel, Gabriele ; Chen, Jie ; Jaensch, Andrea ; Skodda, Lea ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara ; Hvidtfeldt, Ulla Arthur ; Katsouyanni, Klea ; Ketzel, Matthias ; Leander, Karin ; Magnusson, Patrik K.E. ; Pershagen, Göran ; Rizzuto, Debora ; Samoli, Evangelia ; Severi, Gianluca ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel C.H. ; Wolf, Kathrin ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole ; Weinmayr, Gudrun. / Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort : The ELAPSE project. I: International Journal of Cancer. 2024 ; Bind 154, Nr. 11. s. 1900-1910.

Bibtex

@article{4e39995868bc4718827994f4a19127f1,
title = "Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The ELAPSE project",
abstract = "Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone in the warm season (O3w) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM2.5, NO2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00–1.33) per 5 μg/m3 increase in PM2.5, 1.19 (1.08–1.30) per 10 μg/m3 increase in NO2, 1.14 (1.04–1.26) per 0.5 × 10−5 m−1 increase in BC and 0.81 (0.72–0.92) per 10 μg/m3 increase in O3w. We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM2.5, NO2 and BC increased incidence of UADT cancer was observed.",
keywords = "air pollution, gastric cancer, nitrogen dioxide, ozone, particular matter, UADT",
author = "Gabriele Nagel and Jie Chen and Andrea Jaensch and Lea Skodda and Sophia Rodopoulou and Maciej Strak and {de Hoogh}, Kees and Andersen, {Zorana J.} and Tom Bellander and J{\o}rgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Barbara Hoffmann and Hvidtfeldt, {Ulla Arthur} and Klea Katsouyanni and Matthias Ketzel and Karin Leander and Magnusson, {Patrik K.E.} and G{\"o}ran Pershagen and Debora Rizzuto and Evangelia Samoli and Gianluca Severi and Massimo Stafoggia and Anne Tj{\o}nneland and Vermeulen, {Roel C.H.} and Kathrin Wolf and Emanuel Zitt and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen and Gudrun Weinmayr",
note = "Publisher Copyright: {\textcopyright} 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.",
year = "2024",
doi = "10.1002/ijc.34864",
language = "English",
volume = "154",
pages = "1900--1910",
journal = "Acta - Unio Internationalis Contra Cancrum",
issn = "0898-6924",
publisher = "JohnWiley & Sons, Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Long-term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort

T2 - The ELAPSE project

AU - Nagel, Gabriele

AU - Chen, Jie

AU - Jaensch, Andrea

AU - Skodda, Lea

AU - Rodopoulou, Sophia

AU - Strak, Maciej

AU - de Hoogh, Kees

AU - Andersen, Zorana J.

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara

AU - Hvidtfeldt, Ulla Arthur

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Leander, Karin

AU - Magnusson, Patrik K.E.

AU - Pershagen, Göran

AU - Rizzuto, Debora

AU - Samoli, Evangelia

AU - Severi, Gianluca

AU - Stafoggia, Massimo

AU - Tjønneland, Anne

AU - Vermeulen, Roel C.H.

AU - Wolf, Kathrin

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Weinmayr, Gudrun

N1 - Publisher Copyright: © 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

PY - 2024

Y1 - 2024

N2 - Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone in the warm season (O3w) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM2.5, NO2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00–1.33) per 5 μg/m3 increase in PM2.5, 1.19 (1.08–1.30) per 10 μg/m3 increase in NO2, 1.14 (1.04–1.26) per 0.5 × 10−5 m−1 increase in BC and 0.81 (0.72–0.92) per 10 μg/m3 increase in O3w. We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM2.5, NO2 and BC increased incidence of UADT cancer was observed.

AB - Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N = 287,576 participants for gastric and N = 297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone in the warm season (O3w) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. During 5,305,133 and 5,434,843 person-years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM2.5, NO2 and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00–1.33) per 5 μg/m3 increase in PM2.5, 1.19 (1.08–1.30) per 10 μg/m3 increase in NO2, 1.14 (1.04–1.26) per 0.5 × 10−5 m−1 increase in BC and 0.81 (0.72–0.92) per 10 μg/m3 increase in O3w. We found no association between long-term ambient air pollution exposure and incidence of gastric cancer, while for long-term exposure to PM2.5, NO2 and BC increased incidence of UADT cancer was observed.

KW - air pollution

KW - gastric cancer

KW - nitrogen dioxide

KW - ozone

KW - particular matter

KW - UADT

U2 - 10.1002/ijc.34864

DO - 10.1002/ijc.34864

M3 - Journal article

C2 - 38339851

AN - SCOPUS:85184861346

VL - 154

SP - 1900

EP - 1910

JO - Acta - Unio Internationalis Contra Cancrum

JF - Acta - Unio Internationalis Contra Cancrum

SN - 0898-6924

IS - 11

ER -

ID: 383181481