Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort. / Deen, Laura; Clark, Alice; Hougaard, Karin Sørig; Petersen, Kajsa Ugelvig; Frederiksen, Marie; Wise, Lauren A.; Wesselink, Amelia K.; Meyer, Harald William; Bonde, Jens Peter; Tøttenborg, Sandra Søgaard.
I: Environmental Research, Bind 237, 117000, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort
AU - Deen, Laura
AU - Clark, Alice
AU - Hougaard, Karin Sørig
AU - Petersen, Kajsa Ugelvig
AU - Frederiksen, Marie
AU - Wise, Lauren A.
AU - Wesselink, Amelia K.
AU - Meyer, Harald William
AU - Bonde, Jens Peter
AU - Tøttenborg, Sandra Søgaard
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Background: Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. Methods: The register-based ‘Health Effects of PCBs in Indoor Air’ (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. Results: We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCByear) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCByear, the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). Discussion: We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.
AB - Background: Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. Methods: The register-based ‘Health Effects of PCBs in Indoor Air’ (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. Results: We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCByear) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCByear, the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). Discussion: We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.
KW - Environmental pollutants
KW - Lower-chlorinated PCBs
KW - PCBs
KW - Volatile PCBs
U2 - 10.1016/j.envres.2023.117000
DO - 10.1016/j.envres.2023.117000
M3 - Journal article
C2 - 37634693
AN - SCOPUS:85171427837
VL - 237
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 117000
ER -
ID: 369567148