Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire

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Standard

Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire. / Falsey, Ann R.; Walsh, Edward E.; Osborne, Richard H.; Vandendijck, Yannick; Ren, Xiaohui; Witek, James; Kang, Diye; Chan, Eric; Scott, Jane; Ispas, Gabriela.

I: Influenza and Other Respiratory Viruses, Bind 16, Nr. 1, 2022, s. 79-89.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Falsey, AR, Walsh, EE, Osborne, RH, Vandendijck, Y, Ren, X, Witek, J, Kang, D, Chan, E, Scott, J & Ispas, G 2022, 'Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire', Influenza and Other Respiratory Viruses, bind 16, nr. 1, s. 79-89. https://doi.org/10.1111/irv.12903

APA

Falsey, A. R., Walsh, E. E., Osborne, R. H., Vandendijck, Y., Ren, X., Witek, J., Kang, D., Chan, E., Scott, J., & Ispas, G. (2022). Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire. Influenza and Other Respiratory Viruses, 16(1), 79-89. https://doi.org/10.1111/irv.12903

Vancouver

Falsey AR, Walsh EE, Osborne RH, Vandendijck Y, Ren X, Witek J o.a. Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire. Influenza and Other Respiratory Viruses. 2022;16(1):79-89. https://doi.org/10.1111/irv.12903

Author

Falsey, Ann R. ; Walsh, Edward E. ; Osborne, Richard H. ; Vandendijck, Yannick ; Ren, Xiaohui ; Witek, James ; Kang, Diye ; Chan, Eric ; Scott, Jane ; Ispas, Gabriela. / Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire. I: Influenza and Other Respiratory Viruses. 2022 ; Bind 16, Nr. 1. s. 79-89.

Bibtex

@article{ff8538a99b3e47f79a9dfa9da4490cb6,

title = "Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire",

abstract = "Background: The hospitalized acute respiratory tract infection (HARTI) study used the Respiratory Intensity and Impact Questionnaire (RiiQ{\texttrademark}) Symptom Scale, derived from FluiiQ{\texttrademark}, to assess and compare the burden of respiratory infection symptoms for patients with influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) infection, with or without core risk factors (CRF) (age ≥65; chronic heart, renal, obstructive pulmonary disease; asthma). Methods: This was a prospective cohort study in adult patients hospitalized with acute respiratory tract infection (40 centers, 12 countries) during two consecutive influenza/RSV/hMPV seasons (2017–2019). The RiiQ{\texttrademark} Symptom Scale and EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) were assessed by interview at two timepoints during hospitalization and at 1, 2, and 3 months post-discharge. Results: Mean lower respiratory tract (LRT) symptom scores were higher for RSV and hMPV participants compared to influenza at 48 h after enrollment/early discharge (p = 0.001) and 3 months post-discharge (p = 0.007). This was driven by LRT symptoms, including shortness of breath (SOB) (p < 0.01) and wheezing (p < 0.01) during hospitalization, and SOB (p < 0.05) and cough (p < 0.05) post-discharge. Participants with CRF reported more moderate-to-severe SOB (p < 0.05) and wheezing (p < 0.05) compared to CRF(−) participants post-discharge. EQ-5D-5L scores were moderately associated with RiiQ{\texttrademark} LRT and systemic symptoms domains. Conclusions: Results from the HARTI study suggest that in the study population, LRT symptoms were more severe for RSV and hMPV groups and for patients with CRF. RiiQ{\texttrademark} Symptom Scale scores shows a moderate association with EQ-5D-5L indicating that the RiiQ{\texttrademark} may provide useful insights and offer advantages over other measures for use in interventional RSV adult clinical studies.",

keywords = "global prospective study, hMPV, influenza, patient-reported outcomes, RiiQ{\texttrademark}, RSV",

author = "Falsey, {Ann R.} and Walsh, {Edward E.} and Osborne, {Richard H.} and Yannick Vandendijck and Xiaohui Ren and James Witek and Diye Kang and Eric Chan and Jane Scott and Gabriela Ispas",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.",

year = "2022",

doi = "10.1111/irv.12903",

language = "English",

volume = "16",

pages = "79--89",

journal = "Influenza and other Respiratory Viruses",

issn = "1750-2640",

publisher = "Wiley-Blackwell",

number = "1",

}

RIS

TY - JOUR

T1 - Comparative assessment of reported symptoms of influenza, respiratory syncytial virus, and human metapneumovirus infection during hospitalization and post-discharge assessed by Respiratory Intensity and Impact Questionnaire

AU - Falsey, Ann R.

AU - Walsh, Edward E.

AU - Osborne, Richard H.

AU - Vandendijck, Yannick

AU - Ren, Xiaohui

AU - Witek, James

AU - Kang, Diye

AU - Chan, Eric

AU - Scott, Jane

AU - Ispas, Gabriela

PY - 2022

Y1 - 2022

N2 - Background: The hospitalized acute respiratory tract infection (HARTI) study used the Respiratory Intensity and Impact Questionnaire (RiiQ™) Symptom Scale, derived from FluiiQ™, to assess and compare the burden of respiratory infection symptoms for patients with influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) infection, with or without core risk factors (CRF) (age ≥65; chronic heart, renal, obstructive pulmonary disease; asthma). Methods: This was a prospective cohort study in adult patients hospitalized with acute respiratory tract infection (40 centers, 12 countries) during two consecutive influenza/RSV/hMPV seasons (2017–2019). The RiiQ™ Symptom Scale and EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) were assessed by interview at two timepoints during hospitalization and at 1, 2, and 3 months post-discharge. Results: Mean lower respiratory tract (LRT) symptom scores were higher for RSV and hMPV participants compared to influenza at 48 h after enrollment/early discharge (p = 0.001) and 3 months post-discharge (p = 0.007). This was driven by LRT symptoms, including shortness of breath (SOB) (p < 0.01) and wheezing (p < 0.01) during hospitalization, and SOB (p < 0.05) and cough (p < 0.05) post-discharge. Participants with CRF reported more moderate-to-severe SOB (p < 0.05) and wheezing (p < 0.05) compared to CRF(−) participants post-discharge. EQ-5D-5L scores were moderately associated with RiiQ™ LRT and systemic symptoms domains. Conclusions: Results from the HARTI study suggest that in the study population, LRT symptoms were more severe for RSV and hMPV groups and for patients with CRF. RiiQ™ Symptom Scale scores shows a moderate association with EQ-5D-5L indicating that the RiiQ™ may provide useful insights and offer advantages over other measures for use in interventional RSV adult clinical studies.

AB - Background: The hospitalized acute respiratory tract infection (HARTI) study used the Respiratory Intensity and Impact Questionnaire (RiiQ™) Symptom Scale, derived from FluiiQ™, to assess and compare the burden of respiratory infection symptoms for patients with influenza, respiratory syncytial virus (RSV), and human metapneumovirus (hMPV) infection, with or without core risk factors (CRF) (age ≥65; chronic heart, renal, obstructive pulmonary disease; asthma). Methods: This was a prospective cohort study in adult patients hospitalized with acute respiratory tract infection (40 centers, 12 countries) during two consecutive influenza/RSV/hMPV seasons (2017–2019). The RiiQ™ Symptom Scale and EuroQol 5-Dimensions 5-Levels (EQ-5D-5L) were assessed by interview at two timepoints during hospitalization and at 1, 2, and 3 months post-discharge. Results: Mean lower respiratory tract (LRT) symptom scores were higher for RSV and hMPV participants compared to influenza at 48 h after enrollment/early discharge (p = 0.001) and 3 months post-discharge (p = 0.007). This was driven by LRT symptoms, including shortness of breath (SOB) (p < 0.01) and wheezing (p < 0.01) during hospitalization, and SOB (p < 0.05) and cough (p < 0.05) post-discharge. Participants with CRF reported more moderate-to-severe SOB (p < 0.05) and wheezing (p < 0.05) compared to CRF(−) participants post-discharge. EQ-5D-5L scores were moderately associated with RiiQ™ LRT and systemic symptoms domains. Conclusions: Results from the HARTI study suggest that in the study population, LRT symptoms were more severe for RSV and hMPV groups and for patients with CRF. RiiQ™ Symptom Scale scores shows a moderate association with EQ-5D-5L indicating that the RiiQ™ may provide useful insights and offer advantages over other measures for use in interventional RSV adult clinical studies.

KW - global prospective study

KW - hMPV

KW - influenza

KW - patient-reported outcomes

KW - RiiQ™

KW - RSV

U2 - 10.1111/irv.12903

DO - 10.1111/irv.12903

M3 - Journal article

C2 - 34472708

AN - SCOPUS:85114314250

VL - 16

SP - 79

EP - 89

JO - Influenza and other Respiratory Viruses

JF - Influenza and other Respiratory Viruses

SN - 1750-2640

IS - 1

ER -

ID: 291115558