Blood-Biomarkers for Glucose Metabolism in Preterm Infants

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Standard

Blood-Biomarkers for Glucose Metabolism in Preterm Infants. / Bjerager, Mia O.; Hansen, Bo M.; Sørensen, Frederik; Petersen, Jes R.; Jensen, Kristian V.; Hjelvang, Brian R.; Hvelplund, Anna C.; Olsen, Dorte A.; Nielsen, Aneta A.; Forman, Julie L.; Brandslund, Ivan; Greisen, Gorm; Slidsborg, Carina.

I: Biomedicines, Bind 11, Nr. 9, 2377, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bjerager, MO, Hansen, BM, Sørensen, F, Petersen, JR, Jensen, KV, Hjelvang, BR, Hvelplund, AC, Olsen, DA, Nielsen, AA, Forman, JL, Brandslund, I, Greisen, G & Slidsborg, C 2023, 'Blood-Biomarkers for Glucose Metabolism in Preterm Infants', Biomedicines, bind 11, nr. 9, 2377. https://doi.org/10.3390/biomedicines11092377

APA

Bjerager, M. O., Hansen, B. M., Sørensen, F., Petersen, J. R., Jensen, K. V., Hjelvang, B. R., Hvelplund, A. C., Olsen, D. A., Nielsen, A. A., Forman, J. L., Brandslund, I., Greisen, G., & Slidsborg, C. (2023). Blood-Biomarkers for Glucose Metabolism in Preterm Infants. Biomedicines, 11(9), [2377]. https://doi.org/10.3390/biomedicines11092377

Vancouver

Bjerager MO, Hansen BM, Sørensen F, Petersen JR, Jensen KV, Hjelvang BR o.a. Blood-Biomarkers for Glucose Metabolism in Preterm Infants. Biomedicines. 2023;11(9). 2377. https://doi.org/10.3390/biomedicines11092377

Author

Bjerager, Mia O. ; Hansen, Bo M. ; Sørensen, Frederik ; Petersen, Jes R. ; Jensen, Kristian V. ; Hjelvang, Brian R. ; Hvelplund, Anna C. ; Olsen, Dorte A. ; Nielsen, Aneta A. ; Forman, Julie L. ; Brandslund, Ivan ; Greisen, Gorm ; Slidsborg, Carina. / Blood-Biomarkers for Glucose Metabolism in Preterm Infants. I: Biomedicines. 2023 ; Bind 11, Nr. 9.

Bibtex

@article{6e4600f7dece4daab8c903caf90ae7a4,

title = "Blood-Biomarkers for Glucose Metabolism in Preterm Infants",

abstract = "This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool.",

keywords = "blood biomarkers, glucose, healthy reference levels, metabolism, plasma-protein depletion, preterm infants",

author = "Bjerager, {Mia O.} and Hansen, {Bo M.} and Frederik S{\o}rensen and Petersen, {Jes R.} and Jensen, {Kristian V.} and Hjelvang, {Brian R.} and Hvelplund, {Anna C.} and Olsen, {Dorte A.} and Nielsen, {Aneta A.} and Forman, {Julie L.} and Ivan Brandslund and Gorm Greisen and Carina Slidsborg",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

doi = "10.3390/biomedicines11092377",

language = "English",

volume = "11",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "MDPI AG",

number = "9",

}

RIS

TY - JOUR

T1 - Blood-Biomarkers for Glucose Metabolism in Preterm Infants

AU - Bjerager, Mia O.

AU - Hansen, Bo M.

AU - Sørensen, Frederik

AU - Petersen, Jes R.

AU - Jensen, Kristian V.

AU - Hjelvang, Brian R.

AU - Hvelplund, Anna C.

AU - Olsen, Dorte A.

AU - Nielsen, Aneta A.

AU - Forman, Julie L.

AU - Brandslund, Ivan

AU - Greisen, Gorm

AU - Slidsborg, Carina

PY - 2023

Y1 - 2023

N2 - This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool.

AB - This was an exploratory, prospective, longitudinal, cohort study that aimed to establish “healthy” reference levels related to growth parameters and glucose metabolites in preterm infants. This was conducted to further investigate growth and metabolic disturbances potentially related to neonatal illness. The study sample consisted of 108 preterm infants born before 32 weeks in 2018–2019 in the Capital Region of Denmark. Repetitive blood samples were acquired at the neonatal wards, while clinical data were obtained from the regional hospital medical record system. Thirty-four “healthy” preterm infants (31%) were identified. The “ill” infants were divided into four subgroups dependent on gestational age and small for gestational age. Reference levels for the growth parameters and metabolic biomarkers glucose, albumin, and adiponectin, and two glucose control indicators, glycated albumin and fructosamine, were determined for the “healthy” and “ill” subgroups. The “ill” extremely preterm infants had increased glucose levels (mean difference 0.71 mmol/L, 95% CI 0.23; 1.18 mmol/L) and glycated albumin (corrected; %) (mean difference 0.92 mmol/L, 95% CI 0.38 mmol/L;1.47 mmol/L) compared to the “healthy” infants. In “ill” extremely preterm infants and “ill” very preterm infants born small for gestational age, levels of biomarkers containing proteins were decreased. In the “Ill” extremely preterm infants and infants born small for gestational age, postnatal growth was continuously decreased throughout the postconceptional period. The short-term glucose-control indicator, glycated albumin (corrected; %), reflected well the high glucose levels due to its correction for the depleted plasma-protein pool.

KW - blood biomarkers

KW - glucose

KW - healthy reference levels

KW - metabolism

KW - plasma-protein depletion

KW - preterm infants

U2 - 10.3390/biomedicines11092377

DO - 10.3390/biomedicines11092377

M3 - Journal article

C2 - 37760819

AN - SCOPUS:85172469829

VL - 11

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 9

M1 - 2377

ER -

ID: 368970268