A competing risks approach to "biologic" interaction
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.
Originalsprog | Engelsk |
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Tidsskrift | Lifetime Data Analysis |
Vol/bind | 21 |
Udgave nummer | 2 |
Sider (fra-til) | 300-314 |
Antal sider | 15 |
ISSN | 1380-7870 |
DOI | |
Status | Udgivet - apr. 2015 |
ID: 135436589