Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis. / Green, Kent; Kongstad, Thomas; Skov, Marianne; Buchvald, Frederik; Rosthøj, Susanne; Marott, Jacob Louis; Gustafsson, Per; Pressler, Tacjana; Nielsen, Kim Gjerum.
I: Journal of Cystic Fibrosis, Bind 17, Nr. 2, 03.2018, s. 242-248.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Variability of monthly nitrogen multiple-breath washout during one year in children with cystic fibrosis
AU - Green, Kent
AU - Kongstad, Thomas
AU - Skov, Marianne
AU - Buchvald, Frederik
AU - Rosthøj, Susanne
AU - Marott, Jacob Louis
AU - Gustafsson, Per
AU - Pressler, Tacjana
AU - Nielsen, Kim Gjerum
PY - 2018/3
Y1 - 2018/3
N2 - Background:Knowledge of between-session variability of nitrogen multiple-breath washout (N2MBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using N2MBW as end-point. Such information is currently sparse.Methods:Monthly triplets of N2MBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of N2MBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint® vs. Spiroware®).Results:Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p = 0.18); however, variability was significantly higher using Spiroware®.Conclusions:We report between-session variability of LCI using N2MBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint® and Spiroware® can be used interchangeably in longitudinal studies.
AB - Background:Knowledge of between-session variability of nitrogen multiple-breath washout (N2MBW) indices is crucial when designing longitudinal interventional studies and in disease monitoring using N2MBW as end-point. Such information is currently sparse.Methods:Monthly triplets of N2MBW were prospectively obtained from 14 children with CF during one year. Linear mixed models were used to analyze variability. Our aim was to assess between-session variability of N2MBW indices from repeated measurements and compare LCI derived from different software packages currently in use (TestPoint® vs. Spiroware®).Results:Baseline LCI (median; range) was 9.37 (6.82; 12.08). Between-session differences in LCI measurements were up to 25%. Intra Class Correlation-Coefficient was 0.82. There was no systematic difference between LCI measurements derived from the two software packages (p = 0.18); however, variability was significantly higher using Spiroware®.Conclusions:We report between-session variability of LCI using N2MBW in school-age children and adolescents with CF. LCI changes exceeding 25% may be considered clinically relevant. TestPoint® and Spiroware® can be used interchangeably in longitudinal studies.
U2 - 10.1016/j.jcf.2017.11.007
DO - 10.1016/j.jcf.2017.11.007
M3 - Journal article
C2 - 29273421
VL - 17
SP - 242
EP - 248
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
IS - 2
ER -
ID: 189393953