Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men
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- Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men
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Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.
Originalsprog | Engelsk |
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Artikelnummer | 1742 |
Tidsskrift | International Journal of Environmental Research and Public Health |
Vol/bind | 18 |
Udgave nummer | 4 |
Antal sider | 12 |
ISSN | 1661-7827 |
DOI | |
Status | Udgivet - 2021 |
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