Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: Considerations for epidemiological studies
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Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples : Considerations for epidemiological studies. / Frederiksen, Hanne; Kranich, Selma K.; Jørgensen, Niels; Taboureau, Olivier; Petersen, Jørgen H.; Andersson, Anna Maria.
I: Environmental Science & Technology, Bind 47, Nr. 2, 2013, s. 958-967.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples
T2 - Considerations for epidemiological studies
AU - Frederiksen, Hanne
AU - Kranich, Selma K.
AU - Jørgensen, Niels
AU - Taboureau, Olivier
AU - Petersen, Jørgen H.
AU - Andersson, Anna Maria
PY - 2013
Y1 - 2013
N2 - Urinary phthalate excretion is used as marker of phthalate exposure in epidemiological studies. Here we examine the reliability of urinary phthalate levels in exposure classification by comparing the inter- and intrasubject variation of urinary phthalate metabolite levels. Thirty-three young healthy men each collected two spot, three first-morning, and three 24-h urine samples during a 3-month period. Samples were analyzed for the content of 12 urinary metabolites of 7 different phthalates. Variability was assessed as intraclass correlation coefficients (ICC). For the metabolites of diethyl-, dibutyl-, and butylbenzyl-phthalates moderate ICCs were observed in all three sample types, albeit highest in 24-h urine (0.51-0.59). For the metabolites of di(2-ethylhexyl) phthalate and di-iso-nonyl phthlates lower ICCs (0.06-0.29) were found. These low ICCs indicate a high risk of misclassification of exposures for these two phthalates in population studies and hence an attenuation of the power to detect possible exposure-outcome associations. The only slightly higher ICCs for 24-h pools compared to first-morning and spot urine samples does not seem to justify the extra effort needed to collect 24-h pools.
AB - Urinary phthalate excretion is used as marker of phthalate exposure in epidemiological studies. Here we examine the reliability of urinary phthalate levels in exposure classification by comparing the inter- and intrasubject variation of urinary phthalate metabolite levels. Thirty-three young healthy men each collected two spot, three first-morning, and three 24-h urine samples during a 3-month period. Samples were analyzed for the content of 12 urinary metabolites of 7 different phthalates. Variability was assessed as intraclass correlation coefficients (ICC). For the metabolites of diethyl-, dibutyl-, and butylbenzyl-phthalates moderate ICCs were observed in all three sample types, albeit highest in 24-h urine (0.51-0.59). For the metabolites of di(2-ethylhexyl) phthalate and di-iso-nonyl phthlates lower ICCs (0.06-0.29) were found. These low ICCs indicate a high risk of misclassification of exposures for these two phthalates in population studies and hence an attenuation of the power to detect possible exposure-outcome associations. The only slightly higher ICCs for 24-h pools compared to first-morning and spot urine samples does not seem to justify the extra effort needed to collect 24-h pools.
U2 - 10.1021/es303640b
DO - 10.1021/es303640b
M3 - Journal article
C2 - 23234290
AN - SCOPUS:84872543125
VL - 47
SP - 958
EP - 967
JO - Environmental Science & Technology
JF - Environmental Science & Technology
SN - 0013-936X
IS - 2
ER -
ID: 167505783