Robust prediction of t-year survival with data from multiple studies
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Robust prediction of t-year survival with data from multiple studies. / Cai, T; Gerds, Thomas Alexander; Zheng, Y; Chen, J.
I: Biometrics, Bind 67, Nr. 2, 2011, s. 436–444.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Robust prediction of t-year survival with data from multiple studies
AU - Cai, T
AU - Gerds, Thomas Alexander
AU - Zheng, Y
AU - Chen, J
PY - 2011
Y1 - 2011
N2 - Summary Recently meta-analysis has been widely utilized to combine information across multiple studies to evaluate a common effect. Integrating data from similar studies is particularly useful in genomic studies where the individual study sample sizes are not large relative to the number of parameters of interest. In this article, we are interested in developing robust prognostic rules for the prediction of t-year survival based on multiple studies. We propose to construct a composite score for prediction by fitting a stratified semiparametric transformation model that allows the studies to have related but not identical outcomes. To evaluate the accuracy of the resulting score, we provide point and interval estimators for the commonly used accuracy measures including the time-specific receiver operating characteristic curves, and positive and negative predictive values. We apply the proposed procedures to develop prognostic rules for the 5-year survival of breast cancer patients based on five breast cancer genomic studies.
AB - Summary Recently meta-analysis has been widely utilized to combine information across multiple studies to evaluate a common effect. Integrating data from similar studies is particularly useful in genomic studies where the individual study sample sizes are not large relative to the number of parameters of interest. In this article, we are interested in developing robust prognostic rules for the prediction of t-year survival based on multiple studies. We propose to construct a composite score for prediction by fitting a stratified semiparametric transformation model that allows the studies to have related but not identical outcomes. To evaluate the accuracy of the resulting score, we provide point and interval estimators for the commonly used accuracy measures including the time-specific receiver operating characteristic curves, and positive and negative predictive values. We apply the proposed procedures to develop prognostic rules for the 5-year survival of breast cancer patients based on five breast cancer genomic studies.
U2 - 10.1111/j.1541-0420.2010.01462.x
DO - 10.1111/j.1541-0420.2010.01462.x
M3 - Journal article
C2 - 20670303
VL - 67
SP - 436
EP - 444
JO - Biometrics
JF - Biometrics
SN - 0006-341X
IS - 2
ER -
ID: 35058014