Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood : A Meta-Analysis. / Gascon, Mireia; Sunyer, Jordi; Casas, Maribel; Martínez, David; Ballester, Ferran; Basterrechea, Mikel; Bonde, Jens Peter; Chatzi, Leda; Chevrier, Cécile; Eggesbø, Merete; Esplugues, Ana; Govarts, Eva; Hannu, Kiviranta; Ibarluzea, Jesús; Kasper-Sonnenberg, Monika; Klümper, Claudia; Koppen, Gudrun; Nieuwenhuijsen, Mark J; Palkovicova, Lubica; Pelé, Fabienne; Polder, Anuschka; Schoeters, Greet; Torrent, Maties; Trnovec, Tomas; Vassilaki, Maria; Vrijheid, Martine.
I: Epidemiology (Cambridge, Mass.), Bind 25, Nr. 4, 07.2014, s. 544-553.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood
T2 - A Meta-Analysis
AU - Gascon, Mireia
AU - Sunyer, Jordi
AU - Casas, Maribel
AU - Martínez, David
AU - Ballester, Ferran
AU - Basterrechea, Mikel
AU - Bonde, Jens Peter
AU - Chatzi, Leda
AU - Chevrier, Cécile
AU - Eggesbø, Merete
AU - Esplugues, Ana
AU - Govarts, Eva
AU - Hannu, Kiviranta
AU - Ibarluzea, Jesús
AU - Kasper-Sonnenberg, Monika
AU - Klümper, Claudia
AU - Koppen, Gudrun
AU - Nieuwenhuijsen, Mark J
AU - Palkovicova, Lubica
AU - Pelé, Fabienne
AU - Polder, Anuschka
AU - Schoeters, Greet
AU - Torrent, Maties
AU - Trnovec, Tomas
AU - Vassilaki, Maria
AU - Vrijheid, Martine
PY - 2014/7
Y1 - 2014/7
N2 - BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.
AB - BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.
KW - Adolescent
KW - Adult
KW - Bronchitis
KW - Child, Preschool
KW - Cohort Studies
KW - Dichlorodiphenyl Dichloroethylene
KW - Environmental Exposure
KW - Europe
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Poisson Distribution
KW - Polychlorinated Biphenyls
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Respiratory Sounds
KW - Respiratory Tract Diseases
KW - Risk Factors
KW - Young Adult
U2 - 10.1097/EDE.0000000000000097
DO - 10.1097/EDE.0000000000000097
M3 - Journal article
C2 - 24776790
VL - 25
SP - 544
EP - 553
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 4
ER -
ID: 138425957