TY - JOUR

T1 - Low birth weight is associated with earlier onset of end-stage renal disease in Danish patients with autosomal dominant polycystic kidney disease

AU - Orskov, Bjarne

AU - Christensen, Karl Bang

AU - Feldt-Rasmussen, Bo

AU - Strandgaard, Svend

PY - 2012/5

Y1 - 2012/5

N2 - Low-birth-weight individuals have a higher risk of hypertension and end-stage renal disease (ESRD). Here we investigated whether low birth weight was associated with earlier onset of ESRD in patients with autosomal dominant polycystic kidney disease (ADPKD). In collaboration with all Danish departments of nephrology, 307 of 357 patients with ADPKD and ESRD born and living in Denmark were recruited. We were able to analyze complete data of 284 patients obtained from both hospital medical files and midwife protocols in the Danish State Archives. Multivariable linear regression adjusted for birth weight, adult height, mean arterial pressure, gender, birth decade, and type of antihypertensive treatment showed that for every kilogram increase in birth weight, the age at onset of ESRD significantly increased by 1.7 years. Male gender and increased mean arterial pressure were both associated with earlier onset of ESRD. Patients treated with renin-angiotensin system blockade or calcium channel blockers during follow-up had significantly later onset of ESRD by 4.3 years and 2.1 years, respectively. Treatment with beta-blockade or a diuretic was not associated with the age at onset of ESRD. Thus, low birth weight may contribute to considerable phenotypic variability in the progression of renal disease between individuals with ADPKD.

AB - Low-birth-weight individuals have a higher risk of hypertension and end-stage renal disease (ESRD). Here we investigated whether low birth weight was associated with earlier onset of ESRD in patients with autosomal dominant polycystic kidney disease (ADPKD). In collaboration with all Danish departments of nephrology, 307 of 357 patients with ADPKD and ESRD born and living in Denmark were recruited. We were able to analyze complete data of 284 patients obtained from both hospital medical files and midwife protocols in the Danish State Archives. Multivariable linear regression adjusted for birth weight, adult height, mean arterial pressure, gender, birth decade, and type of antihypertensive treatment showed that for every kilogram increase in birth weight, the age at onset of ESRD significantly increased by 1.7 years. Male gender and increased mean arterial pressure were both associated with earlier onset of ESRD. Patients treated with renin-angiotensin system blockade or calcium channel blockers during follow-up had significantly later onset of ESRD by 4.3 years and 2.1 years, respectively. Treatment with beta-blockade or a diuretic was not associated with the age at onset of ESRD. Thus, low birth weight may contribute to considerable phenotypic variability in the progression of renal disease between individuals with ADPKD.

KW - Adult

KW - Age of Onset

KW - Antihypertensive Agents

KW - Chi-Square Distribution

KW - Cross-Sectional Studies

KW - Denmark

KW - Disease Progression

KW - Female

KW - Genetic Predisposition to Disease

KW - Humans

KW - Hypertension

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Kidney Failure, Chronic

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Phenotype

KW - Polycystic Kidney, Autosomal Dominant

KW - Retrospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Time Factors

U2 - 10.1038/ki.2011.459

DO - 10.1038/ki.2011.459

M3 - Journal article

C2 - 22297678

VL - 81

SP - 919

EP - 924

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 9

ER -