Job Strain as a Risk Factor for Type 2 Diabetes: A Pooled Analysis of 124,808 Men and Women
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Job Strain as a Risk Factor for Type 2 Diabetes : A Pooled Analysis of 124,808 Men and Women. / Nyberg, Solja T; Fransson, Eleonor I; Heikkilä, Katriina; Ahola, Kirsi; Alfredsson, Lars; Bjørner, Jakob; Borritz, Marianne; Burr, Hermann; Dragano, Nico; Goldberg, Marcel; Hamer, Mark; Jokela, Markus; Knutsson, Anders; Koskenvuo, Markku; Koskinen, Aki; Kouvonen, Anne; Leineweber, Constanze; Madsen, Ida E H; Magnusson Hanson, Linda L; Marmot, Michael G; Nielsen, Martin L; Nordin, Maria; Oksanen, Tuula; Pejtersen, Jan H; Pentti, Jaana; Rugulies, Reiner; Salo, Paula; Siegrist, Johannes; Steptoe, Andrew; Suominen, Sakari; Theorell, Töres; Väänänen, Ari; Vahtera, Jussi; Virtanen, Marianna; Westerholm, Peter J M; Westerlund, Hugo; Zins, Marie; Batty, G David; Brunner, Eric J; Ferrie, Jane E; Singh-Manoux, Archana; Kivimäki, Mika; IPD-Work Consortium.
I: Diabetes Care, Bind 37, Nr. 8, 08.2014, s. 2268-2275.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Job Strain as a Risk Factor for Type 2 Diabetes
T2 - A Pooled Analysis of 124,808 Men and Women
AU - Nyberg, Solja T
AU - Fransson, Eleonor I
AU - Heikkilä, Katriina
AU - Ahola, Kirsi
AU - Alfredsson, Lars
AU - Bjørner, Jakob
AU - Borritz, Marianne
AU - Burr, Hermann
AU - Dragano, Nico
AU - Goldberg, Marcel
AU - Hamer, Mark
AU - Jokela, Markus
AU - Knutsson, Anders
AU - Koskenvuo, Markku
AU - Koskinen, Aki
AU - Kouvonen, Anne
AU - Leineweber, Constanze
AU - Madsen, Ida E H
AU - Magnusson Hanson, Linda L
AU - Marmot, Michael G
AU - Nielsen, Martin L
AU - Nordin, Maria
AU - Oksanen, Tuula
AU - Pejtersen, Jan H
AU - Pentti, Jaana
AU - Rugulies, Reiner
AU - Salo, Paula
AU - Siegrist, Johannes
AU - Steptoe, Andrew
AU - Suominen, Sakari
AU - Theorell, Töres
AU - Väänänen, Ari
AU - Vahtera, Jussi
AU - Virtanen, Marianna
AU - Westerholm, Peter J M
AU - Westerlund, Hugo
AU - Zins, Marie
AU - Batty, G David
AU - Brunner, Eric J
AU - Ferrie, Jane E
AU - Singh-Manoux, Archana
AU - Kivimäki, Mika
AU - IPD-Work Consortium
N1 - © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
PY - 2014/8
Y1 - 2014/8
N2 - OBJECTIVE: The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle factors, such as obesity and physical inactivity. This collaborative study examined whether stress at work, defined as "job strain," is associated with incident type 2 diabetes independent of lifestyle factors.RESEARCH DESIGN AND METHODS: We extracted individual-level data for 124,808 diabetes-free adults from 13 European cohort studies participating in the IPD-Work Consortium. We measured job strain with baseline questionnaires. Incident type 2 diabetes at follow-up was ascertained using national health registers, clinical screening, and self-reports. We analyzed data for each study using Cox regression and pooled the study-specific estimates in fixed-effect meta-analyses.RESULTS: There were 3,703 cases of incident diabetes during a mean follow-up of 10.3 years. After adjustment for age, sex, and socioeconomic status (SES), the hazard ratio (HR) for job strain compared with no job strain was 1.15 (95% CI 1.06-1.25) with no difference between men and women (1.19 [1.06-1.34] and 1.13 [1.00-1.28], respectively). In stratified analyses, job strain was associated with an increased risk of diabetes among those with healthy and unhealthy lifestyle habits. In a multivariable model adjusted for age, sex, SES, and lifestyle habits, the HR was 1.11 (1.00-1.23).CONCLUSIONS: Findings from a large pan-European dataset suggest that job strain is a risk factor for type 2 diabetes in men and women independent of lifestyle factors.
AB - OBJECTIVE: The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle factors, such as obesity and physical inactivity. This collaborative study examined whether stress at work, defined as "job strain," is associated with incident type 2 diabetes independent of lifestyle factors.RESEARCH DESIGN AND METHODS: We extracted individual-level data for 124,808 diabetes-free adults from 13 European cohort studies participating in the IPD-Work Consortium. We measured job strain with baseline questionnaires. Incident type 2 diabetes at follow-up was ascertained using national health registers, clinical screening, and self-reports. We analyzed data for each study using Cox regression and pooled the study-specific estimates in fixed-effect meta-analyses.RESULTS: There were 3,703 cases of incident diabetes during a mean follow-up of 10.3 years. After adjustment for age, sex, and socioeconomic status (SES), the hazard ratio (HR) for job strain compared with no job strain was 1.15 (95% CI 1.06-1.25) with no difference between men and women (1.19 [1.06-1.34] and 1.13 [1.00-1.28], respectively). In stratified analyses, job strain was associated with an increased risk of diabetes among those with healthy and unhealthy lifestyle habits. In a multivariable model adjusted for age, sex, SES, and lifestyle habits, the HR was 1.11 (1.00-1.23).CONCLUSIONS: Findings from a large pan-European dataset suggest that job strain is a risk factor for type 2 diabetes in men and women independent of lifestyle factors.
U2 - 10.2337/dc13-2936
DO - 10.2337/dc13-2936
M3 - Journal article
C2 - 25061139
VL - 37
SP - 2268
EP - 2275
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 8
ER -
ID: 136796593