Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine. / Toft, Gunnar; Lenters, Virissa; Vermeulen, Roel; Heederik, Dick; Thomsen, Cathrine; Becher, Georg; Giwercman, Aleksander; Bizzaro, Davide; Manicardi, Gian Carlo; Spanò, Marcello; Rylander, Lars; Pedersen, Henning S; Struciński, Paweł; Zviezdai, Valentyna; Bonde, Jens Peter.
I: Reproductive Toxicology, Bind 43, 01.2014, s. 1-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine
AU - Toft, Gunnar
AU - Lenters, Virissa
AU - Vermeulen, Roel
AU - Heederik, Dick
AU - Thomsen, Cathrine
AU - Becher, Georg
AU - Giwercman, Aleksander
AU - Bizzaro, Davide
AU - Manicardi, Gian Carlo
AU - Spanò, Marcello
AU - Rylander, Lars
AU - Pedersen, Henning S
AU - Struciński, Paweł
AU - Zviezdai, Valentyna
AU - Bonde, Jens Peter
PY - 2014/1
Y1 - 2014/1
N2 - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.
AB - Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.
KW - Adult
KW - DNA Damage
KW - Environmental Monitoring
KW - Environmental Pollutants
KW - Estradiol
KW - Flame Retardants
KW - Follicle Stimulating Hormone
KW - Greenland
KW - Halogenated Diphenyl Ethers
KW - Humans
KW - In Situ Nick-End Labeling
KW - Luteinizing Hormone
KW - Male
KW - Poland
KW - Polybrominated Biphenyls
KW - Sperm Count
KW - Sperm Motility
KW - Testosterone
KW - Ukraine
KW - Young Adult
U2 - 10.1016/j.reprotox.2013.10.002
DO - 10.1016/j.reprotox.2013.10.002
M3 - Journal article
C2 - 24513925
VL - 43
SP - 1
EP - 7
JO - Reproductive Toxicology
JF - Reproductive Toxicology
SN - 0890-6238
ER -
ID: 137670346