Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age

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Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age. / Høyer, Birgit Bjerre; Bonde, Jens Peter; Tøttenborg, Sandra Søgaard; Ramlau-Hansen, Cecilia Høst; Lindh, Christian; Pedersen, Henning Sloth; Toft, Gunnar.

I: Hormones and Behavior, Bind 101, 05.2018, s. 105-112.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Høyer, BB, Bonde, JP, Tøttenborg, SS, Ramlau-Hansen, CH, Lindh, C, Pedersen, HS & Toft, G 2018, 'Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age', Hormones and Behavior, bind 101, s. 105-112. https://doi.org/10.1016/j.yhbeh.2017.11.007

APA

Høyer, B. B., Bonde, J. P., Tøttenborg, S. S., Ramlau-Hansen, C. H., Lindh, C., Pedersen, H. S., & Toft, G. (2018). Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age. Hormones and Behavior, 101, 105-112. https://doi.org/10.1016/j.yhbeh.2017.11.007

Vancouver

Høyer BB, Bonde JP, Tøttenborg SS, Ramlau-Hansen CH, Lindh C, Pedersen HS o.a. Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age. Hormones and Behavior. 2018 maj;101:105-112. https://doi.org/10.1016/j.yhbeh.2017.11.007

Author

Høyer, Birgit Bjerre ; Bonde, Jens Peter ; Tøttenborg, Sandra Søgaard ; Ramlau-Hansen, Cecilia Høst ; Lindh, Christian ; Pedersen, Henning Sloth ; Toft, Gunnar. / Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age. I: Hormones and Behavior. 2018 ; Bind 101. s. 105-112.

Bibtex

@article{987362848247468899e2b9ae02c1b564,

title = "Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age",

abstract = "We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N=1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland.",

keywords = "Behaviour, Child, Child development, Cohort study, Fluorocarbons, Prenatal exposure, delayed effects",

author = "H{\o}yer, {Birgit Bjerre} and Bonde, {Jens Peter} and T{\o}ttenborg, {Sandra S{\o}gaard} and Ramlau-Hansen, {Cecilia H{\o}st} and Christian Lindh and Pedersen, {Henning Sloth} and Gunnar Toft",

year = "2018",

month = may,

doi = "10.1016/j.yhbeh.2017.11.007",

language = "English",

volume = "101",

pages = "105--112",

journal = "Hormones and Behavior",

issn = "0018-506X",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age

AU - Høyer, Birgit Bjerre

AU - Bonde, Jens Peter

AU - Tøttenborg, Sandra Søgaard

AU - Ramlau-Hansen, Cecilia Høst

AU - Lindh, Christian

AU - Pedersen, Henning Sloth

AU - Toft, Gunnar

PY - 2018/5

Y1 - 2018/5

N2 - We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N=1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland.

AB - We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5-9years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N=1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland.

KW - Behaviour

KW - Child

KW - Child development

KW - Cohort study

KW - Fluorocarbons

KW - Prenatal exposure, delayed effects

U2 - 10.1016/j.yhbeh.2017.11.007

DO - 10.1016/j.yhbeh.2017.11.007

M3 - Journal article

C2 - 29133180

VL - 101

SP - 105

EP - 112

JO - Hormones and Behavior

JF - Hormones and Behavior

SN - 0018-506X

ER -

ID: 196883298