Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Peanuts are rich in bioactive compounds that may have a positive impact on memory and stress response.
Objective: To evaluate the effect of regular consumption of peanut products on cognitive functions and stress response in healthy young adults.
Design: A three-arm parallel-group randomized controlled trial was conducted in 63 healthy young adults that consumed 25 g/day of skin roasted peanuts (SRP, n = 21), 32 g/d of peanut butter (PB, n = 23) or 32 g/d of a control butter made from peanut oil (free of phenolic compounds and fiber) (CB, n = 19) for six months. Polyphenol intake, cognitive functions, and anxiety and depression scores were evaluated using validated tests. Fecal short-chain fatty acids (SCFAs) and plasma and fecal fatty acids were assessed by chromatographic methods. Urinary cortisol was quantified by an enzymatic method.
Results: Comparing the two interventions with the control, a significant reduction in anxiety scores was observed in the SRP compared to the CB group. After the intervention, consumers of SRP and PB had an improved immediate memory (p = 0.046 and p = 0.011). Lower anxiety scores were associated with SRP and PB (p < 0.001 and p = 0.002, respectively) and lower depression scores with SRP, PB and CB (p = 0.007, p = 0.003 and p = 0.032, respectively). Memory functions and stress response were significantly correlated with polyphenol intake, fecal SCFAs, plasma and fecal very long chain saturated fatty acids (VLCSFAs).
Conclusions: Regular peanut and peanut butter consumption may enhance memory function and stress response in a healthy young population. These effects seem to be associated with the intake of peanut polyphenols, increased levels of fecal SCFAs, and unexpectedly, VLCSFAs, which were also present in the control product.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Nutrition |
| Vol/bind | 40 |
| Udgave nummer | 11 |
| Sider (fra-til) | 5556-5567 |
| Antal sider | 12 |
| ISSN | 0261-5614 |
| DOI | |
| Status | Udgivet - 2021 |
| Eksternt udgivet | Ja |
Bibliografisk note
(Ekstern)
Funding Information:
This research has been supported by the funding from the Peanut Institute 2019, CICYT [AGL2016- 75329-R], CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovaci?n y Universidades, (AEI/FEDER, UE) and Generalitat de Catalunya (GC) [2017SGR 196]. None of the funders had a role in the study design, implementation, analysis or interpretation of the data, or the writing of the manuscript.R.M.L-R reports receiving lecture fees from Cerveceros de Espa?a; and receiving lecture fees and travel support from Adventia. R.E reports personal fees, grants, and nonfinancial support from the California Walnut Commission and Alexion; personal fees and nonfinancial support from Danone; and nonfinancial support from the International Nut Council. Nevertheless, these foundations were not involved in the study design, the collection, analysis and interpretation of data, the writing of the manuscript or the decision to submit the manuscript for publication. The other authors declare no conflict of interest.First, we thank all the volunteers who participated in the ARISTOTLE study. I.P-M. is thankful for the predoctoral scholarship FI-SDUR (EMC/2703/2019). I.D-L. is supported by the (FI_B00256) from the FI-AGAUR research fellowship program, Generalitat de Catalunya. S.C?B. thanks the Spanish Ministry of Science Innovation and Universities for the Formaci?n de Profesorado Universitario (FPU17/00785) contract. M.T-S. is grateful for the APIF 2018?2019 fellowship from the University of Barcelona.
Funding Information:
First, we thank all the volunteers who participated in the ARISTOTLE study. I.P-M. is thankful for the predoctoral scholarship FI-SDUR (EMC/2703/2019). I.D-L. is supported by the (FI_B00256) from the FI-AGAUR research fellowship program , Generalitat de Catalunya . S.C–B. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU17/00785) contract. M.T-S. is grateful for the APIF 2018–2019 fellowship from the University of Barcelona.
Funding Information:
This research has been supported by the funding from the Peanut Institute 2019 , CICYT [AGL2016- 75329-R], CIBEROBN from the Instituto de Salud Carlos III , ISCIII from the Ministerio de Ciencia, Innovación y Universidades , (AEI/FEDER, UE) and Generalitat de Catalunya (GC) [2017SGR 196]. None of the funders had a role in the study design, implementation, analysis or interpretation of the data, or the writing of the manuscript.
Funding Information:
R.M.L-R reports receiving lecture fees from Cerveceros de España ; and receiving lecture fees and travel support from Adventia . R.E reports personal fees, grants, and nonfinancial support from the California Walnut Commission and Alexion ; personal fees and nonfinancial support from Danone ; and nonfinancial support from the International Nut Council . Nevertheless, these foundations were not involved in the study design, the collection, analysis and interpretation of data, the writing of the manuscript or the decision to submit the manuscript for publication. The other authors declare no conflict of interest.
Publisher Copyright:
© 2021 The Author(s)
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