Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men

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Standard

Cadmium may impair prostate function as measured by prostate specific antigen in semen : A cross-sectional study among European and Inuit men. / Andreucci, Alessandro; Mocevic, Emina; Jönsson, Bo A G; Giwercman, Aleksander; Giwercman, Yvonne Lundberg; Toft, Gunnar; Lundh, Thomas; Bizzaro, Davide; Specht, Ina Olmer; Bonde, Jens Peter.

I: Reproductive Toxicology, Bind 53, 06.2015, s. 33-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Andreucci, A, Mocevic, E, Jönsson, BAG, Giwercman, A, Giwercman, YL, Toft, G, Lundh, T, Bizzaro, D, Specht, IO & Bonde, JP 2015, 'Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men', Reproductive Toxicology, bind 53, s. 33-8. https://doi.org/10.1016/j.reprotox.2015.01.010

APA

Andreucci, A., Mocevic, E., Jönsson, B. A. G., Giwercman, A., Giwercman, Y. L., Toft, G., Lundh, T., Bizzaro, D., Specht, I. O., & Bonde, J. P. (2015). Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men. Reproductive Toxicology, 53, 33-8. https://doi.org/10.1016/j.reprotox.2015.01.010

Vancouver

Andreucci A, Mocevic E, Jönsson BAG, Giwercman A, Giwercman YL, Toft G o.a. Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men. Reproductive Toxicology. 2015 jun.;53:33-8. https://doi.org/10.1016/j.reprotox.2015.01.010

Author

Andreucci, Alessandro ; Mocevic, Emina ; Jönsson, Bo A G ; Giwercman, Aleksander ; Giwercman, Yvonne Lundberg ; Toft, Gunnar ; Lundh, Thomas ; Bizzaro, Davide ; Specht, Ina Olmer ; Bonde, Jens Peter. / Cadmium may impair prostate function as measured by prostate specific antigen in semen : A cross-sectional study among European and Inuit men. I: Reproductive Toxicology. 2015 ; Bind 53. s. 33-8.

Bibtex

@article{888d66fbcaaf4627b82f92e6a85686cd,
title = "Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men",
abstract = "We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.",
keywords = "Adolescent, Adult, Cadmium, Cross-Sectional Studies, Greenland, Humans, Inuits, Male, Middle Aged, Poland, Polymorphism, Genetic, Prostate, Prostate-Specific Antigen, Receptors, Androgen, Semen, Ukraine, Young Adult, Zinc",
author = "Alessandro Andreucci and Emina Mocevic and J{\"o}nsson, {Bo A G} and Aleksander Giwercman and Giwercman, {Yvonne Lundberg} and Gunnar Toft and Thomas Lundh and Davide Bizzaro and Specht, {Ina Olmer} and Bonde, {Jens Peter}",
note = "Copyright {\textcopyright} 2015. Published by Elsevier Inc.",
year = "2015",
month = jun,
doi = "10.1016/j.reprotox.2015.01.010",
language = "English",
volume = "53",
pages = "33--8",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cadmium may impair prostate function as measured by prostate specific antigen in semen

T2 - A cross-sectional study among European and Inuit men

AU - Andreucci, Alessandro

AU - Mocevic, Emina

AU - Jönsson, Bo A G

AU - Giwercman, Aleksander

AU - Giwercman, Yvonne Lundberg

AU - Toft, Gunnar

AU - Lundh, Thomas

AU - Bizzaro, Davide

AU - Specht, Ina Olmer

AU - Bonde, Jens Peter

N1 - Copyright © 2015. Published by Elsevier Inc.

PY - 2015/6

Y1 - 2015/6

N2 - We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

AB - We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

KW - Adolescent

KW - Adult

KW - Cadmium

KW - Cross-Sectional Studies

KW - Greenland

KW - Humans

KW - Inuits

KW - Male

KW - Middle Aged

KW - Poland

KW - Polymorphism, Genetic

KW - Prostate

KW - Prostate-Specific Antigen

KW - Receptors, Androgen

KW - Semen

KW - Ukraine

KW - Young Adult

KW - Zinc

U2 - 10.1016/j.reprotox.2015.01.010

DO - 10.1016/j.reprotox.2015.01.010

M3 - Journal article

C2 - 25660730

VL - 53

SP - 33

EP - 38

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -

ID: 162381223