Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations

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Standard

Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations. / Lindh, Christian H; Rylander, Lars; Toft, Gunnar; Axmon, Anna; Rignell-Hydbom, Anna; Giwercman, Aleksander; Pedersen, Henning S; Góalczyk, Katarzyna; Ludwicki, Jan K; Zvyezday, Valentyna; Vermeulen, Roel; Lenters, Virissa; Heederik, Dick; Bonde, Jens Peter; Jönsson, Bo A G.

I: Chemosphere, Bind 88, Nr. 11, 2012, s. 1269-75.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lindh, CH, Rylander, L, Toft, G, Axmon, A, Rignell-Hydbom, A, Giwercman, A, Pedersen, HS, Góalczyk, K, Ludwicki, JK, Zvyezday, V, Vermeulen, R, Lenters, V, Heederik, D, Bonde, JP & Jönsson, BAG 2012, 'Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations', Chemosphere, bind 88, nr. 11, s. 1269-75. https://doi.org/10.1016/j.chemosphere.2012.03.049

APA

Lindh, C. H., Rylander, L., Toft, G., Axmon, A., Rignell-Hydbom, A., Giwercman, A., Pedersen, H. S., Góalczyk, K., Ludwicki, J. K., Zvyezday, V., Vermeulen, R., Lenters, V., Heederik, D., Bonde, J. P., & Jönsson, B. A. G. (2012). Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations. Chemosphere, 88(11), 1269-75. https://doi.org/10.1016/j.chemosphere.2012.03.049

Vancouver

Lindh CH, Rylander L, Toft G, Axmon A, Rignell-Hydbom A, Giwercman A o.a. Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations. Chemosphere. 2012;88(11):1269-75. https://doi.org/10.1016/j.chemosphere.2012.03.049

Author

Lindh, Christian H ; Rylander, Lars ; Toft, Gunnar ; Axmon, Anna ; Rignell-Hydbom, Anna ; Giwercman, Aleksander ; Pedersen, Henning S ; Góalczyk, Katarzyna ; Ludwicki, Jan K ; Zvyezday, Valentyna ; Vermeulen, Roel ; Lenters, Virissa ; Heederik, Dick ; Bonde, Jens Peter ; Jönsson, Bo A G. / Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations. I: Chemosphere. 2012 ; Bind 88, Nr. 11. s. 1269-75.

Bibtex

@article{8e694259ae5b4f1183a2dfb44e6dcf75,

title = "Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations",

abstract = "Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found.",

author = "Lindh, {Christian H} and Lars Rylander and Gunnar Toft and Anna Axmon and Anna Rignell-Hydbom and Aleksander Giwercman and Pedersen, {Henning S} and Katarzyna G{\'o}alczyk and Ludwicki, {Jan K} and Valentyna Zvyezday and Roel Vermeulen and Virissa Lenters and Dick Heederik and Bonde, {Jens Peter} and J{\"o}nsson, {Bo A G}",

year = "2012",

doi = "10.1016/j.chemosphere.2012.03.049",

language = "English",

volume = "88",

pages = "1269--75",

journal = "Chemosphere",

issn = "0045-6535",

publisher = "Pergamon Press",

number = "11",

}

RIS

TY - JOUR

T1 - Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations

AU - Lindh, Christian H

AU - Rylander, Lars

AU - Toft, Gunnar

AU - Axmon, Anna

AU - Rignell-Hydbom, Anna

AU - Giwercman, Aleksander

AU - Pedersen, Henning S

AU - Góalczyk, Katarzyna

AU - Ludwicki, Jan K

AU - Zvyezday, Valentyna

AU - Vermeulen, Roel

AU - Lenters, Virissa

AU - Heederik, Dick

AU - Bonde, Jens Peter

AU - Jönsson, Bo A G

PY - 2012

Y1 - 2012

N2 - Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found.

AB - Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found.

U2 - 10.1016/j.chemosphere.2012.03.049

DO - 10.1016/j.chemosphere.2012.03.049

M3 - Journal article

C2 - 22494529

VL - 88

SP - 1269

EP - 1275

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 11

ER -

ID: 48432085