Association between birth weight and educational attainment: an individual-based pooled analysis of nine twin cohorts
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Association between birth weight and educational attainment : an individual-based pooled analysis of nine twin cohorts. / Jelenkovic, Aline; Mikkonen, Janne; Martikainen, Pekka; Latvala, Antti; Yokoyama, Yoshie; Sund, Reijo; Vuoksimaa, Eero; Rebato, Esther; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Krueger, Robert F.; Mcgue, Matt; Pahlen, Shandell; Nelson, Tracy L.; Whitfield, Keith E.; Brandt, Ingunn; Nilsen, Thomas S.; Harris, Jennifer R.; Cutler, Tessa L.; Hopper, John L.; Tarnoki, Adam D.; Tarnoki, David L.; Sorensen, Thorkild I. A.; Kaprio, Jaakko; Silventoinen, Karri.
I: Journal of Epidemiology and Community Health, Bind 72, Nr. 9, 01.09.2018, s. 832-837.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between birth weight and educational attainment
T2 - an individual-based pooled analysis of nine twin cohorts
AU - Jelenkovic, Aline
AU - Mikkonen, Janne
AU - Martikainen, Pekka
AU - Latvala, Antti
AU - Yokoyama, Yoshie
AU - Sund, Reijo
AU - Vuoksimaa, Eero
AU - Rebato, Esther
AU - Sung, Joohon
AU - Kim, Jina
AU - Lee, Jooyeon
AU - Lee, Sooji
AU - Stazi, Maria A.
AU - Fagnani, Corrado
AU - Brescianini, Sonia
AU - Derom, Catherine A.
AU - Vlietinck, Robert F.
AU - Loos, Ruth J. F.
AU - Krueger, Robert F.
AU - Mcgue, Matt
AU - Pahlen, Shandell
AU - Nelson, Tracy L.
AU - Whitfield, Keith E.
AU - Brandt, Ingunn
AU - Nilsen, Thomas S.
AU - Harris, Jennifer R.
AU - Cutler, Tessa L.
AU - Hopper, John L.
AU - Tarnoki, Adam D.
AU - Tarnoki, David L.
AU - Sorensen, Thorkild I. A.
AU - Kaprio, Jaakko
AU - Silventoinen, Karri
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins. Methods The data were derived from nine twin cohorts in eight countries including 6116 complete twin pairs. The association between birth weight and educational attainment was analysed both between individuals and within pairs using linear regression analyses. Results In between-individual analyses, birth weight was not associated with educational years. Within-pairs analyses revealed positive but modest associations for some sex, zygosity and birth year groups. The greatest association was found in dizygotic (DZ) men (0.65 educational years/kg birth weight, p=0.006); smaller effects of 0.3 educational years/kg birth weight were found within monozygotic (MZ) twins of both sexes and opposite-sex DZ twins. The magnitude of the associations differed by birth year in MZ women and opposite-sex DZ twins, showing a positive association in the 1915-1959 birth cohort but no association in the 1960-1984 birth cohort. Conclusion Although associations are weak and somewhat inconsistent, our results suggest that intrauterine environment may play a role when explaining the association between birth weight and educational attainment.
AB - Background There is evidence that birth weight is positively associated with education, but it remains unclear whether this association is explained by familial environmental factors, genetic factors or the intrauterine environment. We analysed the association between birth weight and educational years within twin pairs, which controls for genetic factors and the environment shared between co-twins. Methods The data were derived from nine twin cohorts in eight countries including 6116 complete twin pairs. The association between birth weight and educational attainment was analysed both between individuals and within pairs using linear regression analyses. Results In between-individual analyses, birth weight was not associated with educational years. Within-pairs analyses revealed positive but modest associations for some sex, zygosity and birth year groups. The greatest association was found in dizygotic (DZ) men (0.65 educational years/kg birth weight, p=0.006); smaller effects of 0.3 educational years/kg birth weight were found within monozygotic (MZ) twins of both sexes and opposite-sex DZ twins. The magnitude of the associations differed by birth year in MZ women and opposite-sex DZ twins, showing a positive association in the 1915-1959 birth cohort but no association in the 1960-1984 birth cohort. Conclusion Although associations are weak and somewhat inconsistent, our results suggest that intrauterine environment may play a role when explaining the association between birth weight and educational attainment.
KW - birth weight
KW - education
KW - twins/genetics
UR - http://www.scopus.com/inward/record.url?scp=85048016386&partnerID=8YFLogxK
U2 - 10.1136/jech-2017-210403
DO - 10.1136/jech-2017-210403
M3 - Journal article
C2 - 29848580
VL - 72
SP - 832
EP - 837
JO - Journal of Epidemiology & Community Health
JF - Journal of Epidemiology & Community Health
SN - 0143-005X
IS - 9
ER -
ID: 209463656