Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure

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  • Pernille Høgh Danielsen
  • Sarah Søs Poulsen
  • Kristina Bram Knudsen
  • Per Axel Clausen
  • Keld Alstrup Jensen
  • Håkan Wallin
  • Ulla Vogel
Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter and SWCNT specific surface area were predictive of lower and higher neutrophil influx, respectively. Manganese and iron were shown to be predictive of higher neutrophil influx at day 1 post-exposure, whereas nickel content interestingly was predictive of lower neutrophil influx at all three time points and of lowered acute phase response at day 1 and 3 months post-exposure. It was not possible to separate effects of properties such as specific surface area and length in the multiple regression analyses due to co-variation.
OriginalsprogEngelsk
Artikelnummer104413
TidsskriftEnvironmental Toxicology and Pharmacology
Vol/bind107
Antal sider11
ISSN1382-6689
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
This work was supported by the Danish Center for Nanosafety, grant # 20110092173-3 from the Danish Working Environment Research Foundation, The Danish Centre for Nanosafety II, the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no 310584 NANoREG, FFIKA, Focused Research Effort on Chemicals in the Working Environment from the Danish Government, the European Union’s Horizon 2020 research and innovation programme under grant agreement 953183 HARMLESS.

Funding Information:
This work was supported by the Danish Centre for Nanosafety, grant # 20110092173-3 from the Danish Working Environment Research Foundation, The Danish Centre for Nanosafety II, the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no 310584 NANoREG, FFIKA, Focused Research Effort on Chemicals in the Working Environment from the Danish Government, the European Union's Horizon 2020 research and innovation programme under grant agreement 953183 HARMLESS.

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