The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer: Sub-study of an RCT

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer : Sub-study of an RCT. / Stormlund, Sacha; Sopa, Negjyp; Lyng Forman, Julie; Zedeler, Anne; Bogstad, Jeanette; Prætorius, Lisbeth; Nielsen, Henriette Svarre; Klajnbard, Anna; Englund, Anne Lis; Ziebe, Søren; Freiesleben, Nina la Cour; Bergh, Christina; Humaidan, Peter; Nyboe Andersen, Anders; Pinborg, Anja; Løssl, Kristine.

I: Human Fertility, Bind 27, Nr. 1, 2265153, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Stormlund, S, Sopa, N, Lyng Forman, J, Zedeler, A, Bogstad, J, Prætorius, L, Nielsen, HS, Klajnbard, A, Englund, AL, Ziebe, S, Freiesleben, NLC, Bergh, C, Humaidan, P, Nyboe Andersen, A, Pinborg, A & Løssl, K 2024, 'The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer: Sub-study of an RCT', Human Fertility, bind 27, nr. 1, 2265153. https://doi.org/10.1080/14647273.2023.2265153

APA

Stormlund, S., Sopa, N., Lyng Forman, J., Zedeler, A., Bogstad, J., Prætorius, L., Nielsen, H. S., Klajnbard, A., Englund, A. L., Ziebe, S., Freiesleben, N. L. C., Bergh, C., Humaidan, P., Nyboe Andersen, A., Pinborg, A., & Løssl, K. (2024). The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer: Sub-study of an RCT. Human Fertility, 27(1), [2265153]. https://doi.org/10.1080/14647273.2023.2265153

Vancouver

Stormlund S, Sopa N, Lyng Forman J, Zedeler A, Bogstad J, Prætorius L o.a. The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer: Sub-study of an RCT. Human Fertility. 2024;27(1). 2265153. https://doi.org/10.1080/14647273.2023.2265153

Author

Stormlund, Sacha ; Sopa, Negjyp ; Lyng Forman, Julie ; Zedeler, Anne ; Bogstad, Jeanette ; Prætorius, Lisbeth ; Nielsen, Henriette Svarre ; Klajnbard, Anna ; Englund, Anne Lis ; Ziebe, Søren ; Freiesleben, Nina la Cour ; Bergh, Christina ; Humaidan, Peter ; Nyboe Andersen, Anders ; Pinborg, Anja ; Løssl, Kristine. / The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer : Sub-study of an RCT. I: Human Fertility. 2024 ; Bind 27, Nr. 1.

Bibtex

@article{4a83549b6a24409a9293e325297d0771,
title = "The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer: Sub-study of an RCT",
abstract = "The effect of late-follicular phase progesterone elevation (LFPE) during ovarian stimulation on reproductive outcomes in ART treatment remains controversial, but recent studies indicate lower pregnancy rates with rising progesterone levels. This study aims to investigate the prevalence of late-follicular phase progesterone elevation (LFPE) and possible impact on ongoing pregnancy rate after fresh or frozen blastocyst transfer in a sub-study setting of a randomised controlled trial. A total of 288 women were included (n=137 and n=151 in the fresh transfer and freeze-all group, respectively). Among these 11(3.8%) had a progesterone level ≥1.5 ng/ml, and 20(6.9%) had a progesterone level ≥1.2 ng/ml on trigger day. Spline regression analysis showed no significant effect of late follicular phase progesterone levels on ongoing pregnancy. In the multivariate regression analysis (n = 312) only age, but not progesterone level on trigger day was significantly associated with ongoing pregnancy. In conclusion, in a clinical setting with moderate gonadotrophin stimulation and well-defined trigger and fresh transfer cancellation criteria, the prevalence of women with LFPE ≥1.5 ng/ml was low and did not indicate the clinical value of routine measurement of progesterone in the late follicular phase.",
keywords = "Female, Humans, Pregnancy, Embryo Transfer, Fertilization in Vitro, Follicular Phase, Ovulation Induction, Pregnancy Rate, Prevalence, Progesterone",
author = "Sacha Stormlund and Negjyp Sopa and {Lyng Forman}, Julie and Anne Zedeler and Jeanette Bogstad and Lisbeth Pr{\ae}torius and Nielsen, {Henriette Svarre} and Anna Klajnbard and Englund, {Anne Lis} and S{\o}ren Ziebe and Freiesleben, {Nina la Cour} and Christina Bergh and Peter Humaidan and {Nyboe Andersen}, Anders and Anja Pinborg and Kristine L{\o}ssl",
year = "2024",
doi = "10.1080/14647273.2023.2265153",
language = "English",
volume = "27",
journal = "Human Fertility",
issn = "1464-7273",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer

T2 - Sub-study of an RCT

AU - Stormlund, Sacha

AU - Sopa, Negjyp

AU - Lyng Forman, Julie

AU - Zedeler, Anne

AU - Bogstad, Jeanette

AU - Prætorius, Lisbeth

AU - Nielsen, Henriette Svarre

AU - Klajnbard, Anna

AU - Englund, Anne Lis

AU - Ziebe, Søren

AU - Freiesleben, Nina la Cour

AU - Bergh, Christina

AU - Humaidan, Peter

AU - Nyboe Andersen, Anders

AU - Pinborg, Anja

AU - Løssl, Kristine

PY - 2024

Y1 - 2024

N2 - The effect of late-follicular phase progesterone elevation (LFPE) during ovarian stimulation on reproductive outcomes in ART treatment remains controversial, but recent studies indicate lower pregnancy rates with rising progesterone levels. This study aims to investigate the prevalence of late-follicular phase progesterone elevation (LFPE) and possible impact on ongoing pregnancy rate after fresh or frozen blastocyst transfer in a sub-study setting of a randomised controlled trial. A total of 288 women were included (n=137 and n=151 in the fresh transfer and freeze-all group, respectively). Among these 11(3.8%) had a progesterone level ≥1.5 ng/ml, and 20(6.9%) had a progesterone level ≥1.2 ng/ml on trigger day. Spline regression analysis showed no significant effect of late follicular phase progesterone levels on ongoing pregnancy. In the multivariate regression analysis (n = 312) only age, but not progesterone level on trigger day was significantly associated with ongoing pregnancy. In conclusion, in a clinical setting with moderate gonadotrophin stimulation and well-defined trigger and fresh transfer cancellation criteria, the prevalence of women with LFPE ≥1.5 ng/ml was low and did not indicate the clinical value of routine measurement of progesterone in the late follicular phase.

AB - The effect of late-follicular phase progesterone elevation (LFPE) during ovarian stimulation on reproductive outcomes in ART treatment remains controversial, but recent studies indicate lower pregnancy rates with rising progesterone levels. This study aims to investigate the prevalence of late-follicular phase progesterone elevation (LFPE) and possible impact on ongoing pregnancy rate after fresh or frozen blastocyst transfer in a sub-study setting of a randomised controlled trial. A total of 288 women were included (n=137 and n=151 in the fresh transfer and freeze-all group, respectively). Among these 11(3.8%) had a progesterone level ≥1.5 ng/ml, and 20(6.9%) had a progesterone level ≥1.2 ng/ml on trigger day. Spline regression analysis showed no significant effect of late follicular phase progesterone levels on ongoing pregnancy. In the multivariate regression analysis (n = 312) only age, but not progesterone level on trigger day was significantly associated with ongoing pregnancy. In conclusion, in a clinical setting with moderate gonadotrophin stimulation and well-defined trigger and fresh transfer cancellation criteria, the prevalence of women with LFPE ≥1.5 ng/ml was low and did not indicate the clinical value of routine measurement of progesterone in the late follicular phase.

KW - Female

KW - Humans

KW - Pregnancy

KW - Embryo Transfer

KW - Fertilization in Vitro

KW - Follicular Phase

KW - Ovulation Induction

KW - Pregnancy Rate

KW - Prevalence

KW - Progesterone

U2 - 10.1080/14647273.2023.2265153

DO - 10.1080/14647273.2023.2265153

M3 - Journal article

C2 - 38639220

VL - 27

JO - Human Fertility

JF - Human Fertility

SN - 1464-7273

IS - 1

M1 - 2265153

ER -

ID: 389841064