The anabolis potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
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The anabolis potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise. / Bechshøft, Rasmus; Dideriksen, K J; Reitelseder, Søren; Scheike, Thomas; Kjær, Michael; Holm, Lars.
I: Clinical Nutrition, Bind 32, Nr. 2, 2013, s. 236-244.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The anabolis potential of dietary protein intake on skeletal muscle is prolonged by prior light-load exercise
AU - Bechshøft, Rasmus
AU - Dideriksen, K J
AU - Reitelseder, Søren
AU - Scheike, Thomas
AU - Kjær, Michael
AU - Holm, Lars
N1 - Copyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
PY - 2013
Y1 - 2013
N2 - Background & aimsHyperaminoacidemia stimulates myofibrillar fractional synthesis rate (myoFSR) transiently in resting skeletal muscle. We investigated whether light-load resistance exercise can extent this responsiveness.MethodsTen healthy males exercised one leg with a light-load resistance-like exercise at 16% of 1 repetition maximum and received oral protein boluses every hour for a 10-h period. Their myoFSR was determined by [1-13C]-leucine incorporation. Muscle biopsies were obtained from the resting (REST) and exercised (EXC) muscles every 2.5-h in the protein-fed period.ResultsProtein feeding significantly elevated plasma leucine and essential amino acids by an average of 39 ± 9% (mean ± SEM) and 20 ± 4%, respectively, compared to the basal concentrations: 197 ± 12 μmol L−1 and 854 ± 35 μmol L−1, respectively. The myoFSR was similar in EXC and REST muscles in the first 8 h (all time intervals p > 0.05). After 8 h the myoFSR dropped in the REST muscle to 0.041 ± 0.005%·h−1, which was 65 ± 5% of the rate in EXC leg at the same time point (0.062 ± 0.004%·h−1) and 80 ± 14% of the level in REST leg from 0.5 to 8 h (0.056 ± 0.005%·h−1) (interaction p < 0.05).ConclusionsCompared to rest, light-load exercise prolonged the stimulatory effect of dietary protein on muscle biosynthesis providing perspectives for a muscle restorative effect in clinical settings where strenuous activity is intolerable.
AB - Background & aimsHyperaminoacidemia stimulates myofibrillar fractional synthesis rate (myoFSR) transiently in resting skeletal muscle. We investigated whether light-load resistance exercise can extent this responsiveness.MethodsTen healthy males exercised one leg with a light-load resistance-like exercise at 16% of 1 repetition maximum and received oral protein boluses every hour for a 10-h period. Their myoFSR was determined by [1-13C]-leucine incorporation. Muscle biopsies were obtained from the resting (REST) and exercised (EXC) muscles every 2.5-h in the protein-fed period.ResultsProtein feeding significantly elevated plasma leucine and essential amino acids by an average of 39 ± 9% (mean ± SEM) and 20 ± 4%, respectively, compared to the basal concentrations: 197 ± 12 μmol L−1 and 854 ± 35 μmol L−1, respectively. The myoFSR was similar in EXC and REST muscles in the first 8 h (all time intervals p > 0.05). After 8 h the myoFSR dropped in the REST muscle to 0.041 ± 0.005%·h−1, which was 65 ± 5% of the rate in EXC leg at the same time point (0.062 ± 0.004%·h−1) and 80 ± 14% of the level in REST leg from 0.5 to 8 h (0.056 ± 0.005%·h−1) (interaction p < 0.05).ConclusionsCompared to rest, light-load exercise prolonged the stimulatory effect of dietary protein on muscle biosynthesis providing perspectives for a muscle restorative effect in clinical settings where strenuous activity is intolerable.
U2 - 10.1016/j.clnu.2012.06.015
DO - 10.1016/j.clnu.2012.06.015
M3 - Journal article
C2 - 22867749
VL - 32
SP - 236
EP - 244
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 2
ER -
ID: 44914207