Telomere length of anterior crucial ligament after rupture: similar telomere length in injured and noninjured ACL portions
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Telomere length of anterior crucial ligament after rupture : similar telomere length in injured and noninjured ACL portions. / Ponsot, Elodie; Langberg, Henning; Krogsgaard, Michael R; Kjaer, Michael; Kadi, Fawzi.
I: Journal of Orthopaedic Research, Bind 29, Nr. 1, 2011, s. 79-83.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Telomere length of anterior crucial ligament after rupture
T2 - similar telomere length in injured and noninjured ACL portions
AU - Ponsot, Elodie
AU - Langberg, Henning
AU - Krogsgaard, Michael R
AU - Kjaer, Michael
AU - Kadi, Fawzi
N1 - Copyright © 2010 Orthopaedic Research Society.
PY - 2011
Y1 - 2011
N2 - The regeneration of ligaments following injury is a slow process compared to the healing of many other tissues and the underlying mechanisms remain unknown. The purpose of the study was to evaluate the proliferative potential of ligaments by assessing telomere length within three distinct parts of human anterior cruciate ligament (ACL) obtained during ACL reconstruction: the macroscopically injured proximal part and macroscopically noninjured mid- and distal portions in eight subjects (age 28 ± 8 years). The mean telomere length in ACL was within normal range of values usually reported for other tissues indicating that the endogenous machinery responsible for the proliferative potential of ligament is not implicated in its poor healing capacity. The three ACL parts showed similar mean TRF lengths (distal part: 11.5 ± 0.8 kbp, mid-portion: 11.8 ± 1.2 kbp, proximal part: 11.9 ± 1.6 kbp) and there was no relationship between mean telomere length in ACL and the healing duration after rupture. This implies that despite the occurrence of ligament repair including a phase of intense cell proliferation the proliferative potential of ruptured ACL is not impaired. This knowledge is important for scientists and clinicians aiming to understand the mechanisms behind the low healing capacity of ligament.
AB - The regeneration of ligaments following injury is a slow process compared to the healing of many other tissues and the underlying mechanisms remain unknown. The purpose of the study was to evaluate the proliferative potential of ligaments by assessing telomere length within three distinct parts of human anterior cruciate ligament (ACL) obtained during ACL reconstruction: the macroscopically injured proximal part and macroscopically noninjured mid- and distal portions in eight subjects (age 28 ± 8 years). The mean telomere length in ACL was within normal range of values usually reported for other tissues indicating that the endogenous machinery responsible for the proliferative potential of ligament is not implicated in its poor healing capacity. The three ACL parts showed similar mean TRF lengths (distal part: 11.5 ± 0.8 kbp, mid-portion: 11.8 ± 1.2 kbp, proximal part: 11.9 ± 1.6 kbp) and there was no relationship between mean telomere length in ACL and the healing duration after rupture. This implies that despite the occurrence of ligament repair including a phase of intense cell proliferation the proliferative potential of ruptured ACL is not impaired. This knowledge is important for scientists and clinicians aiming to understand the mechanisms behind the low healing capacity of ligament.
KW - Adolescent
KW - Adult
KW - Anterior Cruciate Ligament
KW - Female
KW - Humans
KW - Male
KW - Rupture
KW - Telomere
KW - Wound Healing
U2 - 10.1002/jor.21201
DO - 10.1002/jor.21201
M3 - Journal article
C2 - 20629093
VL - 29
SP - 79
EP - 83
JO - Journal of Orthopaedic Research
JF - Journal of Orthopaedic Research
SN - 0736-0266
IS - 1
ER -
ID: 38364051