Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease

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Standard

Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. / Nøjgaard, Camilla; Johansen, Julia S; Christensen, Erik; Skovgaard, Lene Theil; Price, Paul A; Becker, Povl Ulrik.

I: Journal of Hepatology, Bind 39, Nr. 2, 2003, s. 179-186.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nøjgaard, C, Johansen, JS, Christensen, E, Skovgaard, LT, Price, PA & Becker, PU 2003, 'Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease', Journal of Hepatology, bind 39, nr. 2, s. 179-186. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12873813&query_hl=78>

APA

Nøjgaard, C., Johansen, J. S., Christensen, E., Skovgaard, L. T., Price, P. A., & Becker, P. U. (2003). Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. Journal of Hepatology, 39(2), 179-186. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12873813&query_hl=78

Vancouver

Nøjgaard C, Johansen JS, Christensen E, Skovgaard LT, Price PA, Becker PU. Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. Journal of Hepatology. 2003;39(2):179-186.

Author

Nøjgaard, Camilla ; Johansen, Julia S ; Christensen, Erik ; Skovgaard, Lene Theil ; Price, Paul A ; Becker, Povl Ulrik. / Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease. I: Journal of Hepatology. 2003 ; Bind 39, Nr. 2. s. 179-186.

Bibtex

@article{d13ba28074c411dbbee902004c4f4f50,
title = "Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease",
abstract = "BACKGROUND/AIMS: YKL-40 (growth factor) and PIIINP (N-terminal propeptide of Type III procollagen) are potential markers of liver fibrosis. The aim was to evaluate the prognostic value of serum YKL-40 and PIIINP levels in patients with alcoholic liver disease. METHODS: Three hundred and seventy patients with alcoholic liver disease were studied in a trial of malotilate with a median follow-up period of 470 days; 75 patients died; 336 patients had a liver biopsy on entry. Serum levels of YKL-40 and PIIINP were determined by radioimmunoassay (RIA). RESULTS: Serum YKL-40 and PIIINP were elevated in the patients compared to controls. Patients with steatosis or no fibrosis had the lowest serum levels of YKL-40 and PIIINP, whereas patients with alcoholic hepatitis and/or cirrhosis had the highest levels. Serum YKL-40 was associated with the presence of fibrosis, and serum PIIINP was also associated with the different grades of fibrosis. Patients with elevated serum YKL-40 or PIIINP had shorter survival than patients with normal serum levels of YKL-40 (P<0.0001) or PIIINP (P=0.044). High degree of fibrosis predicted shorter survival (P=0.004). CONCLUSIONS: Serum levels of YKL-40 and PIIINP are elevated in alcoholic patients, related to the presence of liver fibrosis and may provide prognostic information.",
author = "Camilla N{\o}jgaard and Johansen, {Julia S} and Erik Christensen and Skovgaard, {Lene Theil} and Price, {Paul A} and Becker, {Povl Ulrik}",
year = "2003",
language = "English",
volume = "39",
pages = "179--186",
journal = "Journal of Hepatology, Supplement",
issn = "0169-5185",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Serum levels of YKL-40 and PIIINP as prognostic markers in patients with alcoholic liver disease

AU - Nøjgaard, Camilla

AU - Johansen, Julia S

AU - Christensen, Erik

AU - Skovgaard, Lene Theil

AU - Price, Paul A

AU - Becker, Povl Ulrik

PY - 2003

Y1 - 2003

N2 - BACKGROUND/AIMS: YKL-40 (growth factor) and PIIINP (N-terminal propeptide of Type III procollagen) are potential markers of liver fibrosis. The aim was to evaluate the prognostic value of serum YKL-40 and PIIINP levels in patients with alcoholic liver disease. METHODS: Three hundred and seventy patients with alcoholic liver disease were studied in a trial of malotilate with a median follow-up period of 470 days; 75 patients died; 336 patients had a liver biopsy on entry. Serum levels of YKL-40 and PIIINP were determined by radioimmunoassay (RIA). RESULTS: Serum YKL-40 and PIIINP were elevated in the patients compared to controls. Patients with steatosis or no fibrosis had the lowest serum levels of YKL-40 and PIIINP, whereas patients with alcoholic hepatitis and/or cirrhosis had the highest levels. Serum YKL-40 was associated with the presence of fibrosis, and serum PIIINP was also associated with the different grades of fibrosis. Patients with elevated serum YKL-40 or PIIINP had shorter survival than patients with normal serum levels of YKL-40 (P<0.0001) or PIIINP (P=0.044). High degree of fibrosis predicted shorter survival (P=0.004). CONCLUSIONS: Serum levels of YKL-40 and PIIINP are elevated in alcoholic patients, related to the presence of liver fibrosis and may provide prognostic information.

AB - BACKGROUND/AIMS: YKL-40 (growth factor) and PIIINP (N-terminal propeptide of Type III procollagen) are potential markers of liver fibrosis. The aim was to evaluate the prognostic value of serum YKL-40 and PIIINP levels in patients with alcoholic liver disease. METHODS: Three hundred and seventy patients with alcoholic liver disease were studied in a trial of malotilate with a median follow-up period of 470 days; 75 patients died; 336 patients had a liver biopsy on entry. Serum levels of YKL-40 and PIIINP were determined by radioimmunoassay (RIA). RESULTS: Serum YKL-40 and PIIINP were elevated in the patients compared to controls. Patients with steatosis or no fibrosis had the lowest serum levels of YKL-40 and PIIINP, whereas patients with alcoholic hepatitis and/or cirrhosis had the highest levels. Serum YKL-40 was associated with the presence of fibrosis, and serum PIIINP was also associated with the different grades of fibrosis. Patients with elevated serum YKL-40 or PIIINP had shorter survival than patients with normal serum levels of YKL-40 (P<0.0001) or PIIINP (P=0.044). High degree of fibrosis predicted shorter survival (P=0.004). CONCLUSIONS: Serum levels of YKL-40 and PIIINP are elevated in alcoholic patients, related to the presence of liver fibrosis and may provide prognostic information.

M3 - Journal article

VL - 39

SP - 179

EP - 186

JO - Journal of Hepatology, Supplement

JF - Journal of Hepatology, Supplement

SN - 0169-5185

IS - 2

ER -

ID: 120530