No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study
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No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study. / Bregenholt, S; Ishøy, T; Skovgaard, L T; Suadicani, P; Appleyard, M; Guldager, B; Malte, L; Gyntelberg, F; Claesson, Mogens Helweg.
I: Acta Pathologica Microbiologica et Immunologica Scandinavica, Bind 109, Nr. 7-8, 2001, s. 517-24.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - No evidence for altered cellular immune functions in personnel deployed in the Persian Gulf during and after the Gulf War--The Danish Gulf War study
AU - Bregenholt, S
AU - Ishøy, T
AU - Skovgaard, L T
AU - Suadicani, P
AU - Appleyard, M
AU - Guldager, B
AU - Malte, L
AU - Gyntelberg, F
AU - Claesson, Mogens Helweg
PY - 2001
Y1 - 2001
N2 - Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p
AB - Veterans who have participated in the Gulf War suffer from a number of symptoms, collectively referred to as the Gulf War Syndrome. It has been hypothesized that a change in the systemic cytokine balance or other changes in immunological parameters could be responsible for some of the symptoms. We analyzed the peripheral blood natural killer (NK) cell activity of 686 Gulf War personnel who had been present in the Persian Gulf area during and immediately after the Gulf War as well as 231 gender and age-matched controls. The test material included individual samples of frozen peripheral blood mononuclear cells kept at -139 degrees C for a period of 50 to 380 days prior to NK cell analysis of freshly thawed cells. Significant differences in NK-cell activity were not observed by direct comparison of the levels of natural cytotoxic activity in the two groups. However, NK-cell cytotoxicity as such decreased due to cryopreservation. Surprisingly, the NK cells obtained from control donors were significantly (p
KW - Adult
KW - Cross-Sectional Studies
KW - Cytokines
KW - Cytotoxicity, Immunologic
KW - Female
KW - Humans
KW - Killer Cells, Natural
KW - Male
KW - Middle Aged
KW - Persian Gulf Syndrome
M3 - Journal article
C2 - 11552949
VL - 109
SP - 517
EP - 524
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 7-8
ER -
ID: 32636103