Multiple sclerosis and organic solvents
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Multiple sclerosis and organic solvents. / Mortensen, J T; Brønnum-Hansen, Henrik; Rasmussen, K.
I: Epidemiology, Bind 9, Nr. 2, 1998, s. 168-171.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Multiple sclerosis and organic solvents
AU - Mortensen, J T
AU - Brønnum-Hansen, Henrik
AU - Rasmussen, K
PY - 1998
Y1 - 1998
N2 - We investigated a possible causal relation between exposure to organic solvents in Danish workers (housepainters, typographers/printers, carpenters/cabinetmakers) and onset of multiple sclerosis. Data on men included in the Danish Multiple Sclerosis Register (3,241 men) were linked with data from the 1970 census from the National Bureau of Statistics in Denmark, which has data on occupational status for 1,768,846 men between 15 and 74 years of age. From this census, we ascertained a group of 124,766 "solvent-exposed" men and an "unexposed" group of 87,501 male electricians, bricklayers, and butchers. Over a follow-up period of 20 years, we observed no increase in the incidence of multiple sclerosis among men presumed to be exposed to organic solvents. It was not possible to obtain data on potential confounders, and the study design has some potential for selection bias. Nevertheless, the study does not support existing hypotheses regarding an association between occupational exposure to organic solvents and multiple sclerosis.
AB - We investigated a possible causal relation between exposure to organic solvents in Danish workers (housepainters, typographers/printers, carpenters/cabinetmakers) and onset of multiple sclerosis. Data on men included in the Danish Multiple Sclerosis Register (3,241 men) were linked with data from the 1970 census from the National Bureau of Statistics in Denmark, which has data on occupational status for 1,768,846 men between 15 and 74 years of age. From this census, we ascertained a group of 124,766 "solvent-exposed" men and an "unexposed" group of 87,501 male electricians, bricklayers, and butchers. Over a follow-up period of 20 years, we observed no increase in the incidence of multiple sclerosis among men presumed to be exposed to organic solvents. It was not possible to obtain data on potential confounders, and the study design has some potential for selection bias. Nevertheless, the study does not support existing hypotheses regarding an association between occupational exposure to organic solvents and multiple sclerosis.
KW - Adolescent
KW - Adult
KW - Aged
KW - Cohort Studies
KW - Denmark
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Multiple Sclerosis
KW - Occupational Exposure
KW - Organic Chemicals
KW - Registries
KW - Solvents
M3 - Journal article
C2 - 9504285
VL - 9
SP - 168
EP - 171
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 2
ER -
ID: 44174176