TY - JOUR

T1 - Incidence of multiple sclerosis in Denmark 1948-1982

T2 - a descriptive nationwide study

AU - Koch-Henriksen, Nils

AU - Brønnum-Hansen, Henrik

AU - Hyllested, K

PY - 1992

Y1 - 1992

N2 - The incidence rates of multiple sclerosis (MS) in Denmark were estimated as a result of a continuous nationwide epidemiological survey since 1948 by the Danish Multiple Sclerosis Registry (DMSR). Among cases notified to the DMSR, 6,478 met the diagnostic criteria and had onset of MS from 1948 through 1982. The crude annual incidence rate was 4.45/100,000 and the lifetime cumulative incidence rate was 0.32%. The female/male ratio was 1.37:1. Crude incidence rates declined during the period 1952-1967. After 1967 the incidence seemed to rise again but in an irregular pattern. The decline in incidence involved only cases up to the age of 35. The subsequent increase was most marked in females and in the age groups over 45 years.

AB - The incidence rates of multiple sclerosis (MS) in Denmark were estimated as a result of a continuous nationwide epidemiological survey since 1948 by the Danish Multiple Sclerosis Registry (DMSR). Among cases notified to the DMSR, 6,478 met the diagnostic criteria and had onset of MS from 1948 through 1982. The crude annual incidence rate was 4.45/100,000 and the lifetime cumulative incidence rate was 0.32%. The female/male ratio was 1.37:1. Crude incidence rates declined during the period 1952-1967. After 1967 the incidence seemed to rise again but in an irregular pattern. The decline in incidence involved only cases up to the age of 35. The subsequent increase was most marked in females and in the age groups over 45 years.

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Cohort Studies

KW - Denmark

KW - Epidemiologic Methods

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Risk

M3 - Journal article

C2 - 1608488

VL - 11

SP - 1

EP - 10

JO - Neuroepidemiology

JF - Neuroepidemiology

SN - 0251-5350

IS - 1

ER -