High Prevalence of Celiac Disease Among Danish Adolescents: A Population-based Study
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High Prevalence of Celiac Disease Among Danish Adolescents : A Population-based Study. / Crawley, Caecilie; Sander, Stine Dydensborg; Nohr, Ellen Aagaard; Lillevang, Søren Thue; Andersen, Anne-Marie Nybo; Murray, Joseph; Husby, Steffen.
I: Journal of Pediatric Gastroenterology and Nutrition, Bind 74, Nr. 1, 2022, s. 85-90.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - High Prevalence of Celiac Disease Among Danish Adolescents
T2 - A Population-based Study
AU - Crawley, Caecilie
AU - Sander, Stine Dydensborg
AU - Nohr, Ellen Aagaard
AU - Lillevang, Søren Thue
AU - Andersen, Anne-Marie Nybo
AU - Murray, Joseph
AU - Husby, Steffen
PY - 2022
Y1 - 2022
N2 - Objectives:The objective of this study was to establish an unselected cohort of Danish adolescents and estimate the prevalence of undiagnosed celiac disease (CeD).Methods:The Glutenfunen cohort participants were recruited from an unselected subsample of the Danish National Birth Cohort, defined as participants living in the Island of Funen, Denmark. We invited all 7431 eligible participants in the age range of 15 to 21 years to a clinical visit. CeD diagnosis was based on screening with IgA transglutaminase antibodies (TG2-IgA) and if positive, was followed by duodenal biopsies compatible with CeD (Marsh 2–3). We calculated the prevalence of CeD in the Glutenfunen cohort as the number of CeD cases diagnosed before and during the study divided by the number of participants in the Glutenfunen cohort.Results:We included 1266 participants in the Glutenfunen cohort (17%, 1266/7431). 1.1% (14 of 1266 participants) had CeD diagnosed before entering the cohort and based on the Danish National Patient Register, 0.2% of the nonparticipants (14 of 6165) had a diagnosis of CeD. In total, 2.6% (33 participants) had TG2 IgA above the upper limit of normal. Nineteen participants had duodenal biopsies compatible with CeD. The prevalence of CeD in the Glutenfunen cohort was 2.6% [(14 + 19)/1266].Conclusions:Our study suggests that CeD is much more common than expected among Danish adolescents, comparable to other European countries, and that the majority were asymptomatic or oligosymptomatic and were only found because of the screening procedure.
AB - Objectives:The objective of this study was to establish an unselected cohort of Danish adolescents and estimate the prevalence of undiagnosed celiac disease (CeD).Methods:The Glutenfunen cohort participants were recruited from an unselected subsample of the Danish National Birth Cohort, defined as participants living in the Island of Funen, Denmark. We invited all 7431 eligible participants in the age range of 15 to 21 years to a clinical visit. CeD diagnosis was based on screening with IgA transglutaminase antibodies (TG2-IgA) and if positive, was followed by duodenal biopsies compatible with CeD (Marsh 2–3). We calculated the prevalence of CeD in the Glutenfunen cohort as the number of CeD cases diagnosed before and during the study divided by the number of participants in the Glutenfunen cohort.Results:We included 1266 participants in the Glutenfunen cohort (17%, 1266/7431). 1.1% (14 of 1266 participants) had CeD diagnosed before entering the cohort and based on the Danish National Patient Register, 0.2% of the nonparticipants (14 of 6165) had a diagnosis of CeD. In total, 2.6% (33 participants) had TG2 IgA above the upper limit of normal. Nineteen participants had duodenal biopsies compatible with CeD. The prevalence of CeD in the Glutenfunen cohort was 2.6% [(14 + 19)/1266].Conclusions:Our study suggests that CeD is much more common than expected among Danish adolescents, comparable to other European countries, and that the majority were asymptomatic or oligosymptomatic and were only found because of the screening procedure.
KW - coeliac autoimmunity
KW - epidemiology
KW - gluten
KW - immunology
KW - screening
U2 - 10.1097/MPG.0000000000003247
DO - 10.1097/MPG.0000000000003247
M3 - Journal article
C2 - 34310439
VL - 74
SP - 85
EP - 90
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 1
ER -
ID: 290516686