Extreme exercise and oxidative DNA modification
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Extreme exercise and oxidative DNA modification. / Poulsen, H E; Loft, S; Vistisen, K.
I: Journal of Sports Sciences, Bind 14, Nr. 4, 08.1996, s. 343-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Extreme exercise and oxidative DNA modification
AU - Poulsen, H E
AU - Loft, S
AU - Vistisen, K
PY - 1996/8
Y1 - 1996/8
N2 - Extreme exercise increases oxygen uptake with a potential for increased formation of reactive oxygen species. Damage to biomolecules may occur if such an increase exceeds the protective capacity of antioxidant defence mechanisms. Vigorous exercise amounting to approximately 10 h a day for 30 days increased the rate of oxidative DNA modification by 33% (95% confidence limits, 3-67%; P < 0.02) in 20 men owing to the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an oxidatively modified deoxynucleoside originating from nuclear DNA repair, oxidation of the nucleotide pool from mitochondrial DNA and/or from cell turnover. Oxidative stress to DNA points to a risk for the development of cancer and premature ageing from extreme exercise.
AB - Extreme exercise increases oxygen uptake with a potential for increased formation of reactive oxygen species. Damage to biomolecules may occur if such an increase exceeds the protective capacity of antioxidant defence mechanisms. Vigorous exercise amounting to approximately 10 h a day for 30 days increased the rate of oxidative DNA modification by 33% (95% confidence limits, 3-67%; P < 0.02) in 20 men owing to the urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an oxidatively modified deoxynucleoside originating from nuclear DNA repair, oxidation of the nucleotide pool from mitochondrial DNA and/or from cell turnover. Oxidative stress to DNA points to a risk for the development of cancer and premature ageing from extreme exercise.
KW - Adult
KW - Aging
KW - Antioxidants
KW - Creatinine
KW - DNA
KW - DNA Damage
KW - DNA Repair
KW - DNA, Mitochondrial
KW - Deoxyguanosine
KW - Exercise
KW - Humans
KW - Male
KW - Neoplasms
KW - Oxidation-Reduction
KW - Oxidative Stress
KW - Oxygen Consumption
KW - Reactive Oxygen Species
KW - Risk Factors
U2 - 10.1080/02640419608727720
DO - 10.1080/02640419608727720
M3 - Journal article
C2 - 8887214
VL - 14
SP - 343
EP - 346
JO - Journal of Sports Sciences
JF - Journal of Sports Sciences
SN - 0264-0414
IS - 4
ER -
ID: 156510081